Browsing by Author "Beretta, Lorenzo"

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A 3-factor epistatic model predicts digital ulcers in Italian scleroderma patients

Beretta, Lorenzo; Santaniello, Alessandro; Mayo, Michael; Cappiello, Francesca; Marchini, Maurizio; Scorza, Raffaella (Elsevier, 2010)

Background The genetic background may predispose systemic sclerosis (SSc) patients to the development of digital ulcers (DUs). Methods Twenty-two functional cytokine single nucleotide polymorphisms (SNPs) and 3 HLA class ...
Evolving concurrent Petri net models of epistasis

Mayo, Michael; Beretta, Lorenzo (2010)

A genetic algorithm is used to learn a non-deterministic Petri netbased model of non-linear gene interactions, or statistical epistasis. Petri nets are computational models of concurrent processes. However, often certain ...
Modelling epistasis in genetic disease using Petri nets, evolutionary computation and frequent itemset mining

Mayo, Michael; Beretta, Lorenzo (Elsevier, 2010)

Petri nets are useful for mathematically modelling disease-causing genetic epistasis. A Petri net model of an interaction has the potential to lead to biological insight into the cause of a genetic disease. However, defining ...