Despite the advantages of shell and tube heat exchangers, one of their major problems is low thermal efficiency. This problem can be improved by using heat transfer enhancement techniques such as adding nanoparticles to the hot or cold fluids, and/or using tube inserts as turbulators on tube side as well as changing baffles to a helical or twisted profile on the shell side. Although all of these techniques increase the thermal efficiency; however, engineers still need a quantitative approach to assess the impact of these technologies on the shell and tube heat exchangers. This study attempts to provide a combination of such techniques to increase the impact of these improvements quantitatively. For this purpose, at first stage the thermal and hydraulic characteristics of pure fluid, Al₂O₃/water nanofluid in a plain tube equipped with and without twisted tape turbulator is evaluated based on a developed rapid design algorithm. Therefore, the impact of using enhanced techniques either in form of individual or in hybrid format and the increase of nanoparticle concentration in base fluid have been studied. The results show that using turbulators individually and in hybrid format with nanofluid can be effected on design parameters of a typical heat exchanger by reducing the required heat transfer area up to 10 %.