General anesthetic-induced seizures can be explained by a mean-field model of cortical dynamics

General anesthetic-induced seizures can be explained by a mean-field model of cortical dynamics

Wilson, Marcus T. ; Sleigh, James W. ; Steyn-Ross, D. Alistair ; Steyn-Ross, Moira L.

Identifier: http://hdl.handle.net/10289/1431

Date: 2006

Citation: Wilson, M. T., Sleigh, J. W., Steyn-Ross, D. A. & Steyn-Ross, M. L. (2006). General anesthetic-induced seizures can be explained by a mean-field model of cortical dynamics. Anesthesiology, 104(3), 588- 593.

Abstract:

In this article, we describe a mathematical model of cerebral cortical function (the so-called mean-field model). We conclude that the technique of mean-field modelling of the cerebral cortex is able to explain parsimoniously and elegantly a constellation of counterintuitive neuropharmacologic experimental data.

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