Base-Free Dynamic Kinetic Resolution of Secondary Alcohols Using “Piano-Stool” Complexes of N-Heterocyclic Carbenes

Base-Free Dynamic Kinetic Resolution of Secondary Alcohols Using “Piano-Stool” Complexes of N-Heterocyclic Carbenes

Marr, Andrew C. ; Pollock, Ciara L. ; Saunders, Graham C.

Identifier: http://hdl.handle.net/10289/2168

Date: 2007

Citation: Marr, A. C., Pollock, C. L. & Saunders, G. C., (2007). Base-Free dynamic kinetic resolution of secondary alcohols using “Piano-stool” complexes of N-heterocyclic carbenes. Organometallics, 26(10), 2659-2671.

Abstract:

“Piano-stool” complexes of rhodium and iridium activated by fluorinated and non-fluorinated N-heterocyclic carbene (NHC) ligands were shown to be catalysts for racemization in the one-pot chemoenzymic dynamic kinetic resolution (DKR) of secondary alcohols. Excellent conversions and good enantioselectivities were observed for alkyl aryl and dialkyl secondary alcohols.

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