Talele, S., Gaynor, P., Cree, M. J. & van Ekeran, J. (2010). Modelling single cell electroporation with bipolar pulse parameters and dynamic pore radii. Journal of Electrostatics, 68(3), 261-174.
Permanent Research Commons link: http://hdl.handle.net/10289/3754
We develop a model of single spherical cell electroporation and simulate spatial and temporal aspects of the transmembrane potential and pore radii as an effect of any form of applied electric field. The extent of electroporation in response to sinusoidal electric pulses of two different frequencies in a range of extracellular conductivity for two different cell radii are compared. Results show that pore radii tend to be more normalized for AC fields. The relative difference in fractional pore area is reduced by the use of a 1 MHz sinusoidal applied electric field over a 100 kHz field.
This is an author’s accepted version of an article published in the journal: Journal of Electrostatics. ©2010 Elsevier B. V.