Daniel, R.M., Cowan, D.A., Morgan, H.W. & Curran, M.P. (1982). A correlation between protein thermostability and resistance to proteolysis. Biochemical Journal, 207(3), 641-644.
Permanent Research Commons link: http://hdl.handle.net/10289/4517
The loss of activity due to proteolysis of purified L-asparaginase and beta-galactosidase from different sources correlates with the thermal instability of the enzymes. A similar correlation is found when populations of soluble proteins from micro-organisms grown at different temperatures are compared for proteolytic susceptibility and thermal stability. It is proposed that there is a general correlation between the thermostability of proteins and their resistance to proteolysis.