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dc.contributor.authorLaird, Dougal Frazer
dc.contributor.authorMucalo, Michael R.
dc.contributor.authorDias, George J.
dc.coverage.spatialUnited Statesen_NZ
dc.date.accessioned2012-10-03T02:14:00Z
dc.date.available2012-10-03T02:14:00Z
dc.date.copyright2012-10-24
dc.date.issued2012
dc.identifier.citationLaird, D. F., Mucalo, M. R., & Dias, G. J. (2012). Vacuum-assisted infiltration of chitosan or polycaprolactone as a structural reinforcement for sintered cancellous bovine bone graft. Journal of Biomedical Materials Research Part A, 100A(10), 2581-2592.en_NZ
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.urihttp://hdl.handle.net/10289/6674
dc.description.abstractSintered cancellous bovine bone (SCBB) offers numerous advantages as a bone graft substitute material; however, its mechanical properties require improvement. In this study, SCBB was infiltrated with ε-polycaprolactone (PCL) or chitosan/monetite to improve mechanical properties while retaining valuable SCBB structure. Organic infiltrating solutions consisted of (i) chitosan and monetite (CaHPO₄) dissolved in hydrochloric acid; (ii) chitosan, monetite (CaHPO₄), and genipin dissolved in hydrochloric acid; or (iii) PCL polymer dissolved in tetrahydrofuran (THF). Porous SCBB materials were infiltrated with one of the three solutions using vacuum-assisted infiltration. Chitosan and CaHPO₄ were immobilized in the SCBB structure by reprecipitation following a pH increase in an ammonia atmosphere. Genipin was used in one sample group to immobilize chitosan via crosslinking. PCL was immobilized by evaporating the THF carrier solvent. Mechanical compression testing showed an improvement in ultimate stress for the SCBB with chitosan/CaHPO₄ infiltrates, whereas PCL samples showed an increase in modulus. All SCBB samples were found to demonstrate favorable in vitro biocompatibility when subjected to L929 mouse fibroblast cells but required a vigorous washing regime to eradicate toxic ammonia residue. In conclusion, infiltration of SCBB with a polymeric or organic/mineral composite matrix positively modifies SCBB mechanical properties in favor of bone grafting applications.en_NZ
dc.language.isoen
dc.publisherWileyen_NZ
dc.relation.ispartofJournal of Biomedical Materials Research Part A
dc.subjectSintered cancellous bovine boneen_NZ
dc.subjectScaffoldsen_NZ
dc.subjectInfiltrationen_NZ
dc.subjectChitosanen_NZ
dc.subjectPolycaprolactoneen_NZ
dc.titleVacuum-assisted infiltration of chitosan or polycaprolactone as a structural reinforcement for sintered cancellous bovine bone graften_NZ
dc.typeJournal Articleen_NZ
dc.identifier.doi10.1002/jbm.a.34193en_NZ
dc.relation.isPartOfJournal of Biomedical Materials Research Part Aen_NZ
pubs.begin-page2581en_NZ
pubs.elements-id37827
pubs.end-page2592en_NZ
pubs.issue10en_NZ
pubs.volume100Aen_NZ


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