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Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish

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dc.contributor.author Husain, Mansourah
dc.contributor.author Bird, Steve
dc.contributor.author Zwieten, Ruthger van
dc.contributor.author Secombes, Christopher J.
dc.contributor.author Wang, Tiehui
dc.date.accessioned 2012-11-19T22:50:46Z
dc.date.available 2012-11-19T22:50:46Z
dc.date.copyright 2012-11
dc.date.issued 2012
dc.identifier.citation Husain, M., Bird, S., Zwieten, R.V., Secombes, C. & Wang, T. (2012). Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish. Developmental and Comparative Immunology, 38(3), 431-446. en_NZ
dc.identifier.issn 0145-305X
dc.identifier.uri http://hdl.handle.net/10289/6863
dc.description.abstract To date two closely related interleukin-1β genes (IL-1β1 and IL-β2) have been found in salmonids. The cloning of trout and salmon IL-1β3., and a salmon IL-1β4 pseudogene reveals that two types of IL-1β genes exist in teleost species. Type I teleost IL-1β genes, including salmonid IL-1β3, share a similar 6 coding exon structure as in tetrapods. Type II teleost IL-1β genes, e.g. salmonid IL-1β1-2, lack one or two coding exons at their 5'-end, and share higher identities within this subgroup than within the type I subgroup. Both types of IL-1β genes have been found in species of Salmoniformes, Perciformes and Beloniformes, suggesting the divergence occurred early in teleost evolution. Trout IL-1β3 is highly expressed in ovary suggesting a role in reproduction. A relatively high constitutive expression in gills, spleen and kidney and the up-regulation by PAMPs, proinflammatory cytokines and viral infection suggests IL-1β3 also has a role in inflammation and host defence. en_NZ
dc.language.iso en
dc.publisher Elsevier en_NZ
dc.relation.ispartof Developmental & Comparative Immunology
dc.subject Atlantic salmon en_NZ
dc.subject Expression en_NZ
dc.subject Gene cloning en_NZ
dc.subject Rainbow trout en_NZ
dc.subject Type I IL-1β en_NZ
dc.subject Type II IL-1β en_NZ
dc.title Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish en_NZ
dc.type Journal Article en_NZ
dc.identifier.doi 10.1016/j.dci.2012.07.010 en_NZ


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