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dc.contributor.authorHusain, Mansourah
dc.contributor.authorBird, Steve
dc.contributor.authorZwieten, Ruthger van
dc.contributor.authorSecombes, Christopher J.
dc.contributor.authorWang, Tiehui
dc.identifier.citationHusain, M., Bird, S., Zwieten, R.V., Secombes, C. & Wang, T. (2012). Cloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fish. Developmental and Comparative Immunology, 38(3), 431-446.en_NZ
dc.description.abstractTo date two closely related interleukin-1β genes (IL-1β1 and IL-β2) have been found in salmonids. The cloning of trout and salmon IL-1β3., and a salmon IL-1β4 pseudogene reveals that two types of IL-1β genes exist in teleost species. Type I teleost IL-1β genes, including salmonid IL-1β3, share a similar 6 coding exon structure as in tetrapods. Type II teleost IL-1β genes, e.g. salmonid IL-1β1-2, lack one or two coding exons at their 5'-end, and share higher identities within this subgroup than within the type I subgroup. Both types of IL-1β genes have been found in species of Salmoniformes, Perciformes and Beloniformes, suggesting the divergence occurred early in teleost evolution. Trout IL-1β3 is highly expressed in ovary suggesting a role in reproduction. A relatively high constitutive expression in gills, spleen and kidney and the up-regulation by PAMPs, proinflammatory cytokines and viral infection suggests IL-1β3 also has a role in inflammation and host defence.en_NZ
dc.relation.ispartofDevelopmental & Comparative Immunology
dc.subjectAtlantic salmonen_NZ
dc.subjectGene cloningen_NZ
dc.subjectRainbow trouten_NZ
dc.subjectType I IL-1βen_NZ
dc.subjectType II IL-1βen_NZ
dc.titleCloning of the IL-1β3 gene and IL-1β4 pseudogene in salmonids uncovers a second type of IL-1β gene in teleost fishen_NZ
dc.typeJournal Articleen_NZ
dc.relation.isPartOfDevelopmental and Comparative Immunologyen_NZ

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