Isolation and identification of a cis-C₈-diol-ester of okadaic acid from Dinophysis acuta in New Zealand
Isolation and identification of a cis-C₈-diol-ester of okadaic acid from Dinophysis acuta in New Zealand
Abstract
A cis-isomer of a C8-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C₈-diol-ester identified in Dinophysis. The more abundant trans-C₈-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.
Type
Journal Article
Type of thesis
Series
Citation
Miles, C. O., Wilkins, A. L., Hawkes, A. D., Jensen, D. J., Cooney, J. M., Larsen, K., Petersen, D., et al. (2006). Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand. Toxicon, 48(2), 195-203.
Date
2006
Publisher
Elsevier