Direct spectral method simulation of the three-dimensional magnetohydrodynamics (MHD) equations is used to explore anisotropy that develops from initially isotropic fluctuations as a consequence of a uniform applied magnetic field. Spectral and variance anisotropies are investigated in both compressible and incompressible MHD. The nature of the spectral anisotropy is consistent with the model of Shebalin et al. [1983] in which the spectrum broadens in the perpendicular wavenumber direction, the anisotropy being greater for smaller wavenumbers. Here this effect is seen for both incompressible and polytropic compressible MHD. In contrast, the longitudinal (compressive) velocity fluctuations remain isotropic. Variance anisotropy is observed for low plasma beta compressible MHD but not for incompressible MHD. Solar wind observations are qualitatively consistent with both variance and spectral anisotropies of the type discussed here.