Barker-Collo, S., Starkey, N. J., & Theadom, A. (2013). Treatment for depression following mild traumatic brain injury in adults: A meta-analysis. Brain Injury, 27(10), 1124–1133. http://doi.org/10.3109/02699052.2013.801513
Permanent Research Commons link: http://hdl.handle.net/10289/8957
Primary objective: Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments. Research design: Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI Method and procedures: PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects. Main outcomes and results: Studies using a pre–post design produced an overall effect size of 1.89 (95% CI = 1.20–2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = −0.44–1.36, p < 0.001), which favoured the control rather than treatment groups. Conclusions: This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.
This is an author’s accepted version of an article published in the journal: Brain Injury. © 2013 Informa UK Ltd.