The sleep cycle modelled as a cortical phase transition

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dc.contributor.authorSteyn-Ross, D. Alistair
dc.contributor.authorSteyn-Ross, Moira L.
dc.contributor.authorSleigh, James W.
dc.contributor.authorWilson, Marcus T.
dc.contributor.authorGillies, Iain-Patrick
dc.contributor.authorWright, J. J.
dc.coverage.spatialConference held at Gothenburg, Sweden:en_NZ
dc.date.accessioned2008-11-20T03:52:32Z
dc.date.available2008-11-20T03:52:32Z
dc.date.issued2005-12
dc.description.abstractWe present a mean-field model of the cortex that attempts to describe the gross changes in brain electrical activity for the cycles of natural sleep. We incorporate within the model two major sleep modulatory effects: slow changes in both synaptic efficiency and in neuron resting voltage caused by the ∼90-min cycling in acetylcholine, together with even slower changes in resting voltage caused by gradual elimination during sleep of somnogens (fatigue agents) such as adenosine. We argue that the change from slow-wave sleep (SWS) to rapid-eye-movement (REM) sleep can be understood as a first-order phase transition from a low-firing, coherent state to a high-firing, desychronized cortical state. We show that the model predictions for changes in EEG power, spectral distribution, and correlation time at the SWS-to-REM transition are consistent not only with those observed in clinical recordings of a sleeping human subject, but also with the on-cortex EEG patterns recently reported by Destexhe et al. [J. Neurosci. 19(11), (1999) 4595–4608] for the sleeping cat.en_US
dc.identifier.citationSteyn-Ross, D. A., Steyn-Ross, M. L., Sleigh, J. W., Wilson, M. T., Gillies, I. P. & Wright, J. J. (2005). The sleep cycle modelled as a cortical phase transition. Journal of Biological Physics, 31(3/4), 547- 569.en_US
dc.identifier.doi10.1007/s10867-005-1285-2en_US
dc.identifier.issn1573-0689
dc.identifier.urihttps://hdl.handle.net/10289/1420
dc.language.isoen
dc.publisherSPRINGERen_NZ
dc.relation.isPartOfJOURNAL OF BIOLOGICAL PHYSICSen_NZ
dc.source5th International Conference on Biological Physics, ICBP 2004en_NZ
dc.subjectcortical modelen_US
dc.subjectsleep cycleen_US
dc.subjectadenosineen_US
dc.subjectacetylcholineen_US
dc.subjectphase transitionen_US
dc.subjectSWSen_US
dc.subjectREMen_US
dc.subjectEEGen_US
dc.subjectLangevin equationen_US
dc.subjectfluctuationsen_US
dc.subjectcorrelationen_US
dc.subjectcritical slowing downen_US
dc.titleThe sleep cycle modelled as a cortical phase transitionen_US
dc.typeJournal Articleen_US
pubs.begin-page547en_NZ
pubs.elements-id14810
pubs.end-page569en_NZ
pubs.finish-date2004-08-27en_NZ
pubs.issue3-4en_NZ
pubs.start-date2004-08-23en_NZ
pubs.volume31en_NZ
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