Isolation and identification of a cis-C₈-diol-ester of okadaic acid from Dinophysis acuta in New Zealand

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dc.contributor.authorMiles, Christopher O.
dc.contributor.authorWilkins, Alistair L.
dc.contributor.authorHawkes, Allan D.
dc.contributor.authorJensen, Dwayne J.
dc.contributor.authorCooney, Janine M.
dc.contributor.authorLarsen, Kristofer
dc.contributor.authorPetersen, Dirk
dc.contributor.authorRise, Frode
dc.contributor.authorBeuzenberg, Veronica
dc.contributor.authorLincoln MacKenzie, A.
dc.date.accessioned2014-01-16T03:05:13Z
dc.date.available2014-01-16T03:05:13Z
dc.date.copyright2006-08
dc.date.issued2006
dc.description.abstractA cis-isomer of a C8-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C₈-diol-ester identified in Dinophysis. The more abundant trans-C₈-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.en_NZ
dc.identifier.citationMiles, C. O., Wilkins, A. L., Hawkes, A. D., Jensen, D. J., Cooney, J. M., Larsen, K., Petersen, D., et al. (2006). Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand. Toxicon, 48(2), 195-203.en_NZ
dc.identifier.doi10.1016/j.toxicon.2006.04.018en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/8400
dc.language.isoenen_NZ
dc.publisherElsevieren_NZ
dc.relation.isPartOfToxiconen_NZ
dc.relation.ispartofToxicon
dc.relation.urihttp://www.sciencedirect.com/science/article/pii/S0041010106001656en_NZ
dc.subjectokadaic aciden_NZ
dc.subjectdiol esteren_NZ
dc.subjectdinophysisen_NZ
dc.subjecthydrolysisen_NZ
dc.subjectmetabolismen_NZ
dc.subjectNMRen_NZ
dc.subjectLC-MSen_NZ
dc.titleIsolation and identification of a cis-C₈-diol-ester of okadaic acid from Dinophysis acuta in New Zealanden_NZ
dc.typeJournal Articleen_NZ
pubs.begin-page195en_NZ
pubs.elements-id34269
pubs.end-page203en_NZ
pubs.issue2en_NZ
pubs.volume48en_NZ
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