Characterisation and expression analysis of B-cell activating factor (BAFF) in spiny dogfish (Squalus acanthias): Cartilaginous fish BAFF has a unique extra exon that may impact receptor binding

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dc.contributor.authorLi, Ronggai
dc.contributor.authorDooley, Helen
dc.contributor.authorWang, Tiehui
dc.contributor.authorSecombes, Christopher J.
dc.contributor.authorBird, Steve
dc.date.accessioned2013-04-19T04:40:59Z
dc.date.available2013-04-19T04:40:59Z
dc.date.copyright2012-04
dc.date.issued2011
dc.description.abstractB-cell activating factor (BAFF), also known as tumour necrosis factor (TNF) ligand superfamily member 13B, is an important immune regulator with critical roles in B-cell survival, proliferation, differentiation and immunoglobulin secretion. A BAFF gene has been cloned from spiny dogfish (Squalus acanthias) and its expression studied. The dogfish BAFF encodes for an anchored type-II transmembrane protein of 288 aa with a putative furin protease cleavage site and TNF family signature as seen in BAFFs from other species. The identity of dogfish BAFF has also been confirmed by conserved cysteine residues, and phylogenetic tree analysis. The dogfish BAFF gene has an extra exon not seen in teleost fish, birds and mammals that encodes for 29 aa and may impact on receptor binding. The dogfish BAFF is highly expressed in immune tissues, such as spleen, and is up-regulated by PWM in peripheral blood leucocytes, suggesting a potentially important role in the immune system.en_NZ
dc.identifier.citationLi, R., Dooley, H., Wang, T., Secombes, C. J., & Bird, S. (2012). Characterisation and expression analysis of B-cell activating factor (BAFF) in spiny dogfish (Squalus acanthias): Cartilaginous fish BAFF has a unique extra exon that may impact receptor binding. Developmental & Comparative Immunology, 36(4), 707-717.en_NZ
dc.identifier.doi10.1016/j.dci.2011.11.010en_NZ
dc.identifier.issn0145-305X
dc.identifier.urihttps://hdl.handle.net/10289/7493
dc.language.isoen
dc.publisherElsevieren_NZ
dc.relation.isPartOfDevelopmental and Comparative Immunologyen_NZ
dc.relation.ispartofDevelopmental & Comparative Immunology
dc.subjectSpiny dogfishen_NZ
dc.subjectBAFFen_NZ
dc.subjectcDNA cloningen_NZ
dc.subjectGene organisationen_NZ
dc.subjectTissue distributionen_NZ
dc.subjectModulation of expressionen_NZ
dc.titleCharacterisation and expression analysis of B-cell activating factor (BAFF) in spiny dogfish (Squalus acanthias): Cartilaginous fish BAFF has a unique extra exon that may impact receptor bindingen_NZ
dc.typeJournal Articleen_NZ
pubs.begin-page707en_NZ
pubs.elements-id37164
pubs.end-page717en_NZ
pubs.issue4en_NZ
pubs.volume36en_NZ
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