Browsing by Author "Martinus, Ryan Dennis"
Now showing items 6-10 of 10
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The effect of complement C5a on mitochondrial functions of PC12 cells
Martinus, Ryan Dennis; Cook, Christian (Lippincott Williams & Wilkins, 2011-08)C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during ... -
Hyperglycaemia and oxidative stress upregulate HSP60 & HSP70 expression in HeLa cells
Hall, Luke; Martinus, Ryan Dennis (Springer, 2013)Heat Shock Proteins 60 & 70 (HSP60 & HSP70) are intracellular protein that has been shown to be present at elevated levels in systemic circulation in Type 2 Diabetes mellitus (T2DM) patients. Conditions that lead to its ... -
Metformin induced expression of Hsp60 in human THP-1 monocyte cells
Tsuei, An-Chi; Martinus, Ryan Dennis (Springer, 2011)Metformin is in widespread clinical use for the treatment of diabetes mellitus in patients. It has been shown to inhibit mitochondrial bioenergetic functions by inhibiting complex I of the electron transport chain. The ... -
Pterocellin A isolated from marine bryozoan Pterocella vesiculosa is cytotoxic to human HeLa cells via mitochondrial apoptotic processes
Wang, Alice Tansi; Prinsep, Michèle R.; Martinus, Ryan Dennis (Springer Verlag, 2016)Pterocellin A is a novel bioactive alkaloid isolated from the New Zealand marine bryozoan Pterocella vesiculosa. It exhibits potent antitumour activity towards the P388 (murine leukaemia) cell line in vitro and is selectively ... -
Role of mitochondrial stress protein HSP60 in diabetes-induced neuroinflammation
Liyanagamage, Donisha Shani Niharika Keembiya; Martinus, Ryan Dennis (Hindawi Limited, 2020)Diabetes mellitus is the most common metabolic disorder characterized by hyperglycemia and associated malfunctions of the metabolism of carbohydrates, proteins, and lipids. There is increasing evidence of a relationship ...