Browsing by Supervisor "Martinus, Ryan Dennis"
Now showing items 1-9 of 9
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Expression of TNF- α at mRNA level in Thp-1 cells exposed to LPS and HSP60: Possible impact on diabetic vascular inflammation
(The University of Waikato, 2018)Diabetes mellitus is a chronic disease characterized by hyperglycaemia. It occurs when the b cells of the pancreas produce either low levels of insulin or no insulin at all. The chronic hyperglycaemic condition of diabetes ... -
In vitro cell culture to study microglial inflammation
(University of Waikato, 2016)Inflammation of the central nervous system (CNS) characterised by release of cytokines such as tumour necrosis factor-alpha (TNF-a) and interleukin-1 (IL-1) is an event that is often detrimental to neuronal cells and is ... -
The Role of Amino Acids and the Threonine-SAM Pathway in the Development of Bovine Inner Cell Mass and Pluripotency
(The University of Waikato, 2018)Pluripotent stem cells (PSCs) are the foundation of all cell types in the body including functional gametes. They are derived either from the inner cell mass (ICM) of preimplantation mouse and rat embryos, known as embryonic ... -
In vitro study of heat shock protein 60 expression and mitochondrial morphology in response to mitochondrial stress in HeLa cells
(University of Waikato, 2015)Diabetes mellitus ( DM) is a metabolic disorder and affecting worldwide as stated by WHO that diabetes will be seventh leading cause of death in 2030. Diabetes mellitus is characterized by hyperglycaemia and the production ... -
Elucidating the Modes of Action of the Antitumour New Zealand Marine Natural Product Pterocellin A
(University of Waikato, 2015)Pterocellin A is a novel bioactive alkaloid isolated from the New Zealand marine bryozoan Pterocella vesiculosa. It exhibits potent antitumour activity towards the P388 (murine leukaemia) cell line in vitro with an IC₅₀ ... -
GFP tagged Hsp60 used to investigate the translocation of Hsp60 in response to mitochondrial stress in HeLa cells
(University of Waikato, 2013)Heat shock protein 60 (Hsp60) is a mitochondrial stress protein that is elevated in response to mitochondrial impairment. It is involved in protein folding and, more recently, it has been identified as a signalling molecule. ... -
A Model In Vitro System to Study Heat Shock Protein 60 (HSP60) Expression in Response to Mitochondrial Impairment in Human Cells
(University of Waikato, 2013)Heat Shock Proteins (HSPs) are a class of ubiquitously expressed and functionally related proteins found in all living organisms from humans to bacteria. Their expression is increased in response to various cellular stressors ... -
RNAi-mediated Reduction of a Major Ruminant Specific Milk Allergen Using a Transgenic Mouse Model
(University of Waikato, 2012)Milk from dairy cows is an important human food. It contains the protein beta-lactoglobulin (BLG) which is not present in human milk and thought to be a major allergen in the milk of cows. RNA interference (RNAi), mediated ... -
Effects of metformin on human monocytic THP-1 cells - Implications for type 2 diabetes mellitus
(The University of Waikato, 2010)Metformin is an anti-hyperglycaemic agent widely prescribed for type 2 diabetes (T2D). Despite decades of clinical use, its exact pharmacological mechanism(s) is yet to be definitively determined. Accumulative data have ...
