Browsing by Supervisor "Arcus, Vickery L."
Now showing items 21-29 of 29
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Structural and enzymatic characterisation of nucleoside triphosphate diphosphohydrolases from Trifolium repens and Dolichos biflorus
(University of Waikato, 2012)Extracellular nucleoside triphosphate diphosphohydrolases (NTPDases) are enzymes that reduce the extracellular nucleotide signal and inactivate the purinogenic signalling pathway. These enzymes, in the presence of a divalent ... -
Testing Macromolecular Rate Theory
(University of Waikato, 2017)Enzymatic rate increase with respect to temperature has widely been described by transition-state theory. The experimentally observed rate decline above an optimum temperature (Tₒₚₜ) for enzymes has previously been attributed ... -
The Biology and Biochemistry of PhoH2 proteins
(University of Waikato, 2013)PhoH2 proteins are found in a diverse range of organisms. To date little is known about these proteins and the role they play in the organisms in which they reside. PhoH2 is a PIN PhoH domain fusion, and these proteins are ... -
The evolution of AroA and MurA enzymes from Bacillus
(University of Waikato, 2016)MurA and AroA are important antibacterial targets due to their essentiality in microorganisms and the absence of their respective pathways within mammals. Although much research has focussed on these enzymes, little is ... -
The structure and function of a bovine salivary protein - BSP30b
(The University of Waikato, 2019)The Bovine Salivary Protein 30b (BSP30b) is a member of the palate, lung, and nasal epithelium clone (PLUNC) family which includes human bactericidal/permeability-increasing protein (BPI) and lipopolysaccaride binding ... -
Time to Diagnosis and Persistence: The Two Major Determinants of Effective Tuberculosis Control
(University of Waikato, 2015)The greatest challenge confronting effective tuberculosis (TB) eradication is the time to diagnosis, and duration of treatment of chronically infected individuals which represent a pool of infection. In an attempt to help ... -
Understanding allosteric enzyme regulation using macromolecular rate theory
(The University of Waikato, 2020)Enzyme catalysed reaction rates produce a curved temperature dependence with a temperature optimum, Topt. Traditionally enzyme temperature dependence has been modelled by the Arrhenius and Eyring-Polanyi equations. Deviations ... -
Understanding enzymatic mechanism and allostery using macromolecular rate theory
(The University of Waikato, 2022)Intricate systems of regulation at many levels act to control enzyme rates to tune metabolism across biosynthetic pathways. Allostery is a ubiquitous regulatory mechanism for feedback and regulation of enzymes in biosynthetic ... -
Verifying clustered mutation regions inside the newly-completed genome of a clinically-significant New Zealand Mycobacterium tuberculosis strain
(The University of Waikato, 2021)In 2019, active infections of Mycobacterium tuberculosis (Mtb) affected 10 million people globally, with 1.4 million deaths, and an additional 1.7-1.9 billion people infected without symptomatic disease (latent Mtb). While ...
