Browsing by Author "Olszewski, Pawel K."
Now showing items 6-10 of 10
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Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans
Olszewski, Pawel K.; Rozman, Jane; Jacobsson, Josefin A.; Rathkolb, Birgit; Stromberg, Siv; Hans, Wolfgang; Klockars, Anica; Alsiö, Johan; Riserus, Ulf; Becker, Lore; Holter, Sabine; Elvert, Ralf; Ehrhardt, Nicole; Gailus-Durner, Valérie; Fuchs, Helmut; Fredriksson, Robert; Wolf, Eckhard; Klopstock, Thomas; Wurst, Wolfgang; Levine, Allen S.; Marcus, Claude; de Angelis, Martin Hrabě; Klingenspor, Martin; Schiöth, Helgi B.; Kilimann, Manfred W. (Public Library of Science, 2012)Neurobeachin (Nbea) regulates neuronal membrane protein trafficking and is required for the development and functioning of central and neuromuscular synapses. In homozygous knockout (KO) mice, Nbea deficiency causes perinatal ... -
The orphan G protein-coupled receptor gene GPR178 is evolutionary conserved and altered in response to acute changes in food intake
Caruso, Vanni; Le Grevés, Madeleine; Fard, Shahrzad Shirazi; Haitina, Tatjana; Olszewski, Pawel K.; Alsiö, Johan; Schiöth, Helgi B.; Fredriksson, Robert (Public Library of Science, 2015-06-05)G protein-coupled receptors (GPCRs) are a class of integral membrane proteins mediating physiological functions fundamental for survival, including energy homeostasis. A few years ago, an amino acid sequence of a novel ... -
Oxytocin receptor blockade reduces acquisition but not retrieval of taste aversion and blunts responsiveness of amygdala neurons to an aversive stimulus
Olszewski, Pawel K.; Waas, Joseph R.; Brooks, Lydia L.; Herisson, Florence; Levine, Allen S. (Elsevier, 2013)When gastrointestinal sickness induced by toxin injection is associated with exposure to novel food, the animal acquires a conditioned taste aversion (CTA). Malaise is accompanied by a surge in oxytocin release and in ... -
Palatability of Goat's versus Cow's Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models.
Klockars, Anica; Wood, Erin Lavinia; Gartner, Sarah Nicole; McColl, Laura Kathryn; Levine, Allen S.; Carpenter, Elizabeth A.; Prosser, Colin G.; Olszewski, Pawel K. (2019)Goat's (GM) and cow's milk (CM) are dietary alternatives with select health benefits shown in human and animal studies. Surprisingly, no systematic analysis of palatability or preference for GM vs. CM has been performed ... -
Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain
Jacobson, Gregory M.; Voss, Logan J.; Klockars, Anica; Bird, Steve; Dimitrov, Ivo; Denny, William A.; Olszewski, Pawel K.; Sleigh, James W.; Harvey, Martyn G. (BMC, 2019)Background Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces ...