Browsing by Author "Becker, Torsten"

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  • Direct determination of vibrational density of states change on ligand binding to a protein

    Balog, Erika; Becker, Torsten; Oettl, Martin; Lechner, Ruep; Daniel, Roy M.; Finney, John L.; Smith, Jeremy C. (American Physical Society, 2004)
    The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly ...
  • Neutron frequency windows and the protein dynamical transition

    Becker, Torsten; Hayward, Jennifer A.; Finney, John L.; Daniel, Roy M.; Smith, Jeremy C. (Biophysical Society, 2004-09)
    Proteins undergo an apparent dynamical transition on temperature variation that has been correlated with the onset of function. The transition in the mean-square displacement, ∆r2 , that is observed using a spectrometer ...