Browsing by Author "Cook, Gregory M."

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  • Complete genome sequence of a New Zealand Mycobacterium tuberculosis strain responsible for ongoing transmission over the past 30 years.

    Mulholland, Claire V.; Gimenez, Gregory; Williamson, Adele; Steele, Mackenzie; Thorpe, Duncan; Karalus, Noel; Cursons, Raymond T.; Playle, Veronica M.; Roberts, Sally A.; Cook, Gregory M.; Arcus, Vickery L.; Aung, Htin Lin (2022)
    We report here the complete genome sequence of Mycobacterium tuberculosis strain Colonial S-type 1 (CS1), which has been responsible for ongoing outbreaks of tuberculosis in New Zealand over the past 30 years. CS1 appears ...
  • Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry

    McKenzie, Joanna Leigh; Duyvestyn, Johanna Maria; Smith, Tony C.; Bendak, Katerina; Mackay, Joel P.; Cursons, Raymond T.; Cook, Gregory M.; Arcus, Vickery L. (RNA Society, 2012)
    The VapBC toxin-antitoxin (TA) family is the largest of nine identified TA families. The toxin, VapC, is a metal-dependent ribonuclease that is inhibited by its cognate antitoxin, VapB. Although the VapBCs are the largest ...
  • The PIN-domain ribonucleases and the prokaryotic VapBC toxin–antitoxin array

    Arcus, Vickery L.; McKenzie, Joanna Leigh; Robson, Jennifer R.; Cook, Gregory M. (Oxford University Press, 2010)
    The PIN-domains are small proteins of ∼130 amino acids that are found in bacteria, archaea and eukaryotes and are defined by a group of three strictly conserved acidic amino acids. The conserved three-dimensional structures ...
  • Ribonucleases in bacterial toxin–antitoxin systems

    Cook, Gregory M.; Robson, Jennifer R.; Frampton, Rebekah A.; McKenzie, Joanna Leigh; Przybilski, Rita; Fineran, Peter C.; Arcus, Vickery L. (Elsevier, 2013)
    Toxin-antitoxin (TA) systems are widespread in bacteria and archaea and play important roles in a diverse range of cellular activities. TA systems have been broadly classified into 5 types and the targets of the toxins are ...
  • Toxin-antitoxin systems of mycobacterium smegmatis are essential for cell survival

    Frampton, Rebekah A.; Aggio, Rachael B.M.; Villas-Bôas, Silas G; Arcus, Vickery L.; Cook, Gregory M. (American Society for Biochemistry and Molecular Biology, 2011)
    The role of chromosomal toxin-antitoxin (TA) modules in bacterial physiology remains enigmatic despite their abundance in the genomes of many bacteria. Mycobacterium smegmatis contains three putative TA systems, VapBC, ...