Now showing items 1-5 of 7

  • The dependence of enzyme activity on temperature: determination and validation of parameters

    Peterson, Michelle E.; Daniel, Roy M.; Danson, Michael J.; Eisenthal, Robert (Portland Press (Online), 2007)
    Traditionally, the dependence of enzyme activity on temperature has been described by a model consisting of two processes: the catalytic reaction defined by DGDaggercat, and irreversible inactivation defined by DGDaggerinact. ...
  • Eurythermalism and the temperature dependence of enzyme activity

    Lee, Charles Kai-Wu; Daniel, Roy M.; Shepherd, Charis; Saul, David; Cary, S. Craig; Danson, Michael J.; Eisenthal, Robert; Peterson, Michelle E. (Federation of American Societies for Experimental Biology, 2007)
    The "Equilibrium Model" has provided new tools for describing and investigating enzyme thermal adaptation. It has been shown that the effect of temperature on enzyme activity is not only governed by ΔG‡cat and ΔG‡inact but ...
  • A new intrinsic thermal parameter for enzymes reveals true temperature optima

    Peterson, Michelle E.; Eisenthal, Robert; Danson, Michael J.; Spence, Alastair; Daniel, Roy M. (The American Society for Biochemistry and Molecular Biology, Inc., 2004)
    Two established thermal properties of enzymes are the Arrhenius activation energy and thermal stability. Arising from anomalies found in the variation of enzyme activity with temperature, a comparison has been made of ...
  • New parameters controlling the effect of temperature on enzyme activity

    Daniel, Roy M.; Danson, Michael J.; Eisenthal, Robert; Lee, Charles Kai-Wu; Peterson, Michelle E. (Portland Press, 2007)
    Arising from careful measurements of the thermal behaviour of enzymes, a new model, the Equilibrium Model, has been developed to explain more fully the effects of temperature on enzymes. The model describes the effect of ...
  • Review: The effect of temperature on enzyme activity: new insights and their implications

    Daniel, Roy M.; Danson, Michael J.; Eisenthal, Robert; Lee, Charles Kai-Wu; Peterson, Michelle E. (2007)
    The two established thermal properties of enzymes are their activation energy and their thermal stability. Arising from careful measurements of the thermal behaviour of enzymes, a new model, the Equilibrium Model, has been ...