Browsing by Author "Kelton, William"
Now showing items 1-5 of 5
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Beyond allotypes: The influence of allelic diversity in antibody constant domains
(Frontiers Media SA, 2020)Polymorphic diversity in antibody constant domains has long been defined by allotypic motifs that cross react with the sera of other individuals. Improvements in sequencing technologies have led to the discovery of a large ... -
Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain.
(2022)The continual evolution of SARS-CoV-2 and the emergence of variants that show resistance to vaccines and neutralizing antibodies threaten to prolong the COVID-19 pandemic. Selection and emergence of SARS-CoV-2 variants are ... -
Immunogenic fusion proteins induce neutralizing SARS-CoV-2 antibodies in the serum and milk of sheep
(Elsevier B. V., 2023-06)Antigen-specific polyclonal immunoglobulins derived from the serum, colostrum, or milk of immunized ruminant animals have potential as scalable therapeutics for the control of viral diseases including COVID-19. Here we ... -
Impact of prepartum administration of a vaccine against infectious calf diarrhea on nonspecific colostral immunoglobulin concentrations of dairy cows.
(2022-06-09)Passive transfer of colostral immunoglobulins from the cow to the calf is essential for calf health. The objective of this study was to determine if prepartum administration of a vaccine stimulates increased concentrations ... -
Mechanisms of host manipulation by Neisseria gonorrhoeae
(Frontiers Media SA, 2023-02-03)Neisseria gonorrhoeae (also known as gonococcus) has been causing gonorrhoea in humans since ancient Egyptian times. Today, global gonorrhoea infections are rising at an alarming rate, in concert with an increasing number ...
Co-authors for William Kelton
Supervised by William Kelton
Showing up to 5 theses - most recently added to Research Commons first.
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The influence of constant region polymorphisms on antibody stability and structural dynamics
(The University of Waikato, 2023)Antibodies are highly effective mediators of the adaptive immune response. Their unique structural architecture makes them ideally suited for the specific targeting of disease-causing agents and the subsequent activation ...
