Browsing by Author "Kurkal, Vandana"

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  • Dynamics of immobilized and native Escherichia coli dihydrofolate reductase by quasielastic neutron scattering

    Tehei, Moeava; Smith, Jeremy C.; Monk, Colin R.; Ollivier, Jacques; Oettl, Martin; Kurkal, Vandana; Finney, John L.; Daniel, Roy M. (Biophysical Society, 2006-10)
    The internal dynamics of native and immobilized Escherichia coli dihydrofolate reductase (DHFR) have been examined using incoherent quasielastic neutron scattering. These results reveal no difference between the high ...
  • Enzyme activity and flexibility at very low hydration

    Kurkal, Vandana; Daniel, Roy M.; Finney, John L.; Tehei, Moeava; Dunn, Rachel V.; Smith, Jeremy C. (Biophysical Society, 2005-05)
    Recent measurements have demonstrated enzyme activity at hydrations as low as 3%. This raises the question of whether hydration-induced enzyme flexibility is important for activity. Here, to address this, picosecond dynamic ...
  • Low frequency enzyme dynamics as a function of temperature and hydration: A neutron scattering study

    Kurkal, Vandana; Daniel, Roy M.; Finney, John L.; Tehei, M.; Dunn, Rachel V.; Smith, Jeremy C. (Elsevier, 2005)
    The effect of hydration and temperature on the low-frequency dynamics of the enzyme Pig liver esterase has been investigated with incoherent neutron scattering experiments. The results suggest that at low temperature, ...