Browsing by Author "Martinus, Ryan Dennis"
Now showing items 1-5 of 8
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Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism
(Elsevier, 2013)Angiopoietin-like protein 2 (Angptl2) levels are increased by obesity and obesity-related pathological conditions, and it is considered to be an important adipocyte-derived inflammatory mediator. In contrast, the multifunctional ... -
A comparative proteomics study of skeletal muscle mitochondria from myostatin null mice
(Portland Press Ltd, 2011)Myostatin is a secreted protein which is known to be a negative regulator of skeletal muscle growth. Numerous studies have demonstrated that down-regulating the expression of myostatin results in an increase in muscle mass. ... -
Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects
(Springer, 2011)There is increasing evidence that mitochondrial dysfunction and oxidative stress may be integral to the pathogenesis of type 2 diabetes mellitus. Heat shock protein (Hsp60) is a mitochondrial stress protein known to be ... -
Does Hsp60 provide a link between mitochondrial stress and inflammation in Diabetes Mellitus?
(Hindawi Publishing Corporation, 2016)The focus of this review is to summarise the known relationships between the expression of Heat Shock Protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 Diabetes Mellitus. Hsp60 is a mitochondrial ... -
The effect of complement C5a on mitochondrial functions of PC12 cells
(Lippincott Williams & Wilkins, 2011-08)C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during ...
Co-authors for Ryan Dennis Martinus
Supervised by Ryan Dennis Martinus
Showing up to 5 theses - most recently added to Research Commons first.
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Expression of TNF- α at mRNA level in Thp-1 cells exposed to LPS and HSP60: Possible impact on diabetic vascular inflammation
(The University of Waikato, 2018)Diabetes mellitus is a chronic disease characterized by hyperglycaemia. It occurs when the b cells of the pancreas produce either low levels of insulin or no insulin at all. The chronic hyperglycaemic condition of diabetes ... -
In vitro cell culture to study microglial inflammation
(University of Waikato, 2016)Inflammation of the central nervous system (CNS) characterised by release of cytokines such as tumour necrosis factor-alpha (TNF-a) and interleukin-1 (IL-1) is an event that is often detrimental to neuronal cells and is ... -
In vitro study of heat shock protein 60 expression and mitochondrial morphology in response to mitochondrial stress in HeLa cells
(University of Waikato, 2015)Diabetes mellitus ( DM) is a metabolic disorder and affecting worldwide as stated by WHO that diabetes will be seventh leading cause of death in 2030. Diabetes mellitus is characterized by hyperglycaemia and the production ... -
Elucidating the Modes of Action of the Antitumour New Zealand Marine Natural Product Pterocellin A
(University of Waikato, 2015)Pterocellin A is a novel bioactive alkaloid isolated from the New Zealand marine bryozoan Pterocella vesiculosa. It exhibits potent antitumour activity towards the P388 (murine leukaemia) cell line in vitro with an IC₅₀ ... -
GFP tagged Hsp60 used to investigate the translocation of Hsp60 in response to mitochondrial stress in HeLa cells
(University of Waikato, 2013)Heat shock protein 60 (Hsp60) is a mitochondrial stress protein that is elevated in response to mitochondrial impairment. It is involved in protein folding and, more recently, it has been identified as a signalling molecule. ...
