Browsing by Author "McKenzie, Joanna Leigh"
Now showing items 1-5 of 6
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The Biochemistry of VapBC Toxin-Antitoxins
(University of Waikato, 2011)The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria ... -
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry
(RNA Society, 2012)The VapBC toxin-antitoxin (TA) family is the largest of nine identified TA families. The toxin, VapC, is a metal-dependent ribonuclease that is inhibited by its cognate antitoxin, VapB. Although the VapBCs are the largest ... -
The PIN-domain ribonucleases and the prokaryotic VapBC toxin–antitoxin array
(Oxford University Press, 2010)The PIN-domains are small proteins of ∼130 amino acids that are found in bacteria, archaea and eukaryotes and are defined by a group of three strictly conserved acidic amino acids. The conserved three-dimensional structures ... -
Ribonucleases in bacterial toxin–antitoxin systems
(Elsevier, 2013)Toxin-antitoxin (TA) systems are widespread in bacteria and archaea and play important roles in a diverse range of cellular activities. TA systems have been broadly classified into 5 types and the targets of the toxins are ... -
Structure and Function of AmtR in Mycobacterium smegmatis: Implications for Post-Transcriptional Regulation of Urea Metabolism through a Small Antisense RNA
(ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 2016-10-23)Soil-dwelling bacteria of the phylum actinomycetes generally harbor either GlnR or AmtR as a global regulator of nitrogen metabolism. Mycobacterium smegmatis harbors both of these canonical regulators; GlnR regulates the ...
