Now showing items 1-5 of 5

  • The Biochemistry of VapBC Toxin-Antitoxins

    McKenzie, Joanna Leigh (University of Waikato, 2011)
    The VapBC toxin-antitoxin (TA) systems were first identified in 2005 and little is known about their contemporary biological function, despite the fact that VapBC TAs are the largest TA family and are widespread in bacteria ...
  • Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry

    McKenzie, Joanna Leigh; Duyvestyn, Johanna Maria; Smith, Tony C.; Bendak, Katerina; Mackay, Joel P.; Cursons, Raymond T.; Cook, Gregory M.; Arcus, Vickery L. (RNA Society, 2012)
    The VapBC toxin-antitoxin (TA) family is the largest of nine identified TA families. The toxin, VapC, is a metal-dependent ribonuclease that is inhibited by its cognate antitoxin, VapB. Although the VapBCs are the largest ...
  • The PIN-domain ribonucleases and the prokaryotic VapBC toxin–antitoxin array

    Arcus, Vickery L.; McKenzie, Joanna Leigh; Robson, Jennifer R.; Cook, Gregory M. (Oxford University Press, 2010)
    The PIN-domains are small proteins of ∼130 amino acids that are found in bacteria, archaea and eukaryotes and are defined by a group of three strictly conserved acidic amino acids. The conserved three-dimensional structures ...
  • Ribonucleases in bacterial toxin–antitoxin systems

    Cook, Gregory M.; Robson, Jennifer R.; Frampton, Rebekah A.; McKenzie, Joanna Leigh; Przybilski, Rita; Fineran, Peter C.; Arcus, Vickery L. (Elsevier, 2013)
    Toxin-antitoxin (TA) systems are widespread in bacteria and archaea and play important roles in a diverse range of cellular activities. TA systems have been broadly classified into 5 types and the targets of the toxins are ...
  • VapC Toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins

    Ahidjo, Bintou Ahmadou; Kuhnert, Diane; McKenzie, Joanna Leigh; Machowski, Edith E.; Gordhan, Bhavna G.; Arcus, Vickery L.; Abrahams, Garth L.; Mizrahi, Valerie (-online, 2011)
    The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion ...