Browsing by Author "Oback, Bjorn"

• Bovine blastocyst development depends on threonine catabolism 

  Najafzadeh, V.; Henderson, H.; Martinus, Ryan Dennis; Oback, Bjorn (Cold Spring Harbor Laboratory, 2018)

  Increasing evidence suggests that pluripotency is a metabolically specialised state. In mouse, inner cell mass (ICM) cells and ICM-derived pluripotent stem cells (PSCs) critically depend on catabolising the amino acid ...

  

• The Role of Amino Acids and the Threonine-SAM Pathway in the Development of Bovine Inner Cell Mass and Pluripotency 

  Najafzadeh, Vahid (The University of Waikato, 2018)

  Pluripotent stem cells (PSCs) are the foundation of all cell types in the body including functional gametes. They are derived either from the inner cell mass (ICM) of preimplantation mouse and rat embryos, known as embryonic ...

  

• Using putative bovine embryonic stem cell-like cells for nuclear transfer cloning to determine their functional potential 

  Appleby, Sarah Jane (University of Waikato, 2015)

  The potential for cloning to improve dissemination of elite genetics has been a goal of livestock scientists for many years. However, efficiency of this technique has remained low compared to other in vitro embryo production ...

  

• Doxycycline-inducible overexpression of NANOG in bovine fibroblasts and nuclear transfer embryos 

  Chibnall, Alice Margaret (University of Waikato, 2015)

  Naïve pluripotent embryonic stem cells (ES cells) have the ability to give rise to all cell types including functional gametes. These cells have been well established in mice and rats. The potential for biomedical and ...

  

• Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos 

  Kallingappa, Prasanna Kumar (University of Waikato, 2013)

  Cloning by somatic cell nuclear transfer (SCNT) forces cells to lose their lineage-specific epigenetic marks and become totipotent again. This reprogramming process often results in epigenetic and transcriptional aberrations ...

  

• Inhibition of ERK and GSK3 signalling pathways promotes development and expression of pluripotent markers in bovine blastocysts 

  Harris, Daina (University of Waikato, 2012)

  Embryo-derived pluripotent stem cells (ePSCs) naturally derive from different founder tissues, namely the early and late epiblast, that vary in their cellular characteristics. Recent evidence in mice suggests these sources ...

  

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