Browsing by Author "Sleigh, James W."

Now showing items 1-5 of 45

  • Aconitine induces prolonged seizure-like events in rat neocortical brain slices

    Voss, Logan J.; Voss, Janet M.; McLeay, Lance M.; Sleigh, James W. (Elsevier BV, 2008)
    Aconitine effects on the hippocampal slice preparation have been well documented and include acute inhibitory and prolonged excitatory effects. To date, the effect of aconitine on neocortical activity has not been investigated. ...
  • An analysis of the transitions between down and up states of the cortical slow oscillation under urethane anaesthesia

    Wilson, Marcus T.; Barry, Melissa; Reynolds, John N.J.; Crump, William P.; Steyn-Ross, D. Alistair; Steyn-Ross, Moira L.; Sleigh, James W. (Springer Netherlands, 2010)
    We study the dynamics of the transition between the low- and high-firing states of the cortical slow oscillation by using intracellular recordings of the membrane potential from cortical neurons of rats. We investigate the ...
  • Anesthesia-induced state transitions in neuronal populations

    Sleigh, James W.; Steyn-Ross, Moira L.; Steyn-Ross, D. Alistair; Voss, Logan J.; Wilson, Marcus T. (Humana Press., 2010)
    It is a simple observation that the function of the central nervous system changes abruptly at certain critical brain concentrations of the anesthetic drug. This can be viewed as analogous to “state transitions” in systems ...
  • Association of innate immune single-nucleotide polymorphisms with the electroencephalogram during desflurane general anaesthesia

    Mulholland, Claire Vignette; Somogyi, Andrew Alexander; Barratt, Daniel Thomas; Coller, Janet Kristie; Hutchinson, Mark Rowland; Jacobson, Gregory M.; Cursons, Raymond T.; Sleigh, James W. (Springer, 2013)
    The electroencephalogram (EEG) records the electrical activity of the brain and enables effects of anaesthetic drugs on brain functioning to be monitored. Identification of genes contributing to EEG variability during ...
  • The Bispectral Index: A measure of depth of sleep?

    Sleigh, James W.; Andrzejowski, John; Steyn-Ross, D. Alistair; Steyn-Ross, Moira L. (LIPPINCOTT WILLIAMS & WILKINS, 1999)
    How does physiological sleep affect the Bispectral Index (BIS)? We collected electroencephalographic (EEG) data from five subjects during the early part of the night, comparing the changes in the BIS with the conventional ...

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