Browsing by Author "Voss, Logan J."

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  • Aconitine induces prolonged seizure-like events in rat neocortical brain slices

    Voss, Logan J.; Voss, Janet M.; McLeay, Lance M.; Sleigh, James W. (Elsevier BV, 2008)
    Aconitine effects on the hippocampal slice preparation have been well documented and include acute inhibitory and prolonged excitatory effects. To date, the effect of aconitine on neocortical activity has not been investigated. ...
  • Anesthesia-induced state transitions in neuronal populations

    Sleigh, James W.; Steyn-Ross, Moira L.; Steyn-Ross, D. Alistair; Voss, Logan J.; Wilson, Marcus T. (Humana Press., 2010)
    It is a simple observation that the function of the central nervous system changes abruptly at certain critical brain concentrations of the anesthetic drug. This can be viewed as analogous to “state transitions” in systems ...
  • Changes in frequency of seizure-like events in stimulated cortical slices

    Mason, J.; Voss, Logan J.; Jacobson, Gregory M.; Elbohouty, Maher; Sleigh, James W.; Steyn-Ross, Moira L.; Steyn-Ross, D. Alistair (IEEE Xplore, 2010)
    Epilepsy affects nearly 3 million people in the United States alone. Given the fact that many people suffer from seizures that are intractable to pharmacological intervention, research groups are investigating the use of ...
  • Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors

    Jacobson, Gregory M.; Voss, Logan J.; Melin, Sofia M.; Mason, Jonathan P.; Cursons, Raymond T.; Steyn-Ross, D. Alistair; Steyn-Ross, Moira L.; Sleigh, James W. (Elsevier, 2010)
    Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure ...
  • A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep

    Sleigh, James W.; Wilson, Marcus T.; Voss, Logan J.; Steyn-Ross, D. Alistair; Steyn-Ross, Moira L.; Li, Xiaoli (Springer, 2010)
    Previous studies have shown that activated cortical states (awake and rapid eye-movement (REM) sleep), are associated with increased cholinergic input into the cerebral cortex. However, the mechanisms that underlie the ...

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