Browsing by Subject "substrate-specificity"

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Structure of a eukaryotic nonribosomal peptide synthetase adenylation domain that activates a large hydroxamate amino acid in siderophore biosynthesis

Lee, T. Verne; Johnson, Linda J.; Johnson, Richard D.; Koulman, Albert; Lane, Geoffrey A.; Lott, J. Shaun; Arcus, Vickery L. (The American Society for Biochemistry and Molecular Biology, 2010)

Nonribosomal peptide synthetases (NRPSs) are large, multidomain proteins that are involved in the biosynthesis of an array of secondary metabolites. We report the structure of the third adenylation domain from the ...