Browsing by Supervisor "Olszewski, Pawel K."
Now showing items 1-20 of 24
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Anorexigenic effects of naltrexone in rats
(The University of Waikato, 2023)The accessibility of cheap, palatable, and caloric food in the industrialized world has shifted the primary drive of eating behavior from hunger to pleasure; this change has played a significant role in the rise in the ... -
Characterisation of an acute anorexigenic action of l-tryptophan: a link with neural mechanisms regulating appetite
(The University of Waikato, 2018)Recent evidence suggests that individual amino acids may promote hypophagia, however, our understanding of processes underlying their anorexigenic action is extremely limited. The few human and laboratory animal studies ... -
Characterisation of Food Intake and Expression of Feeding-Related Genes in The VPA Rat Model of Autism Spectrum Disorder
(University of Waikato, 2017)Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting roughly 1% of the global population. Aberrant food selectivity (AFS) is a common comorbid symptom of ASD which can result in nutritional deficiencies, ... -
Comparative hypoxia responses and oxygen sensing in galaxiid fishes
(The University of Waikato, 2017)Aquatic ecosystems are inherently characterised by limited oxygen availability and fluctuations in dissolved oxygen concentration, and therefore, environmental hypoxia (i.e. low oxygen conditions) is common. However, in ... -
Connexin 36 as a Regulator of Consummatory Behaviour
(University of Waikato, 2014)Gap junctions enable metabolic and electrical coupling of adjacent cells. Connexin 36 (Cx36) is a gap junction protein found predominantly in mammalian neurons. Because Cx36 is expressed in many areas involved in the ... -
Dietary supplementation and intragastric infusions of L-tryptophan reduce food intake
(University of Waikato, 2016)Select free amino acids have been suggested to promote early satiation. Initial studies indicate that L-tryptophan may play an important role in reducing appetite. The current set of experiments examined whether dietary ... -
Eating behaviour regulation in Zebrafish (Danio rerio): a comparative analysis
(University of Waikato, 2014)The structure, function, and tissue specific expression profiles of neuropeptides involved in regulating eating behaviour are well researched in mammals, the corresponding literature on fish homologs however is scarce. The ... -
Effect of novel ketamine-analogue R5 on brain activation and select behavioural parameters
(The University of Waikato, 2017)Ketamine is a common anaesthetic that works through complex neural mechanisms, including multiple molecular and circuitry targets. Importantly, it promotes analgesia, though it also induces undesirable effects, such as ... -
Effects of naltrexone on energy- and palatability-driven consumption and neuronal activation in feeding-related forebrain areas: relationship with age
(University of Waikato, 2017)Intake of energy as well as interest in palatable foods diminish during the ageing process. One of the likely reasons underlying this phenomenon is an age-related decrease in the opioid tone in the brain. To further ... -
Effects of oxytocin on feeding suppression and neuronal activity in aged mice
(The University of Waikato, 2022)Many studies have shown that, compared to younger adults, old individuals show a different sensitivity to various pharmacological treatments. This phenomenon stems from a plethora of physiological and pathophysiological ... -
Exposure to familiar versus novel conspecifics is associated with differential activity of oxytocin circuits
(University of Waikato, 2015)Oxytocin (OT) signalling has been shown to be significantly involved in the regulation of social behaviour, particularly in regards to pro-sociality. Familiarity with another conspecific is a major modifier of social ... -
Goat’s vs cow’s milk consumption: Analysis of feeding behaviour, brain activation and gene expression in laboratory animals
(The University of Waikato, 2021)Milk is a complex and highly nutritive food. In Western societies, cow’s milk (CM) is most commonly consumed, but recent years have generated interest in milk from other species, especially in goat’s milk (GM). Importantly, ... -
Gossypol's effects on ingestive behaviour in mice: The first step in a systematic process to define gossypol's suitability for use in murine pest management
(University of Waikato, 2014)Gossypol, synthesised by the cotton plant, Gossypium, causes physiological and behavioural changes in mammals, suggesting it may be suitable for murine pest management. One of the most under-studied responses to gossypol, ... -
Grazing and feeding management to reduce urinary nitrogen excretion and enteric methane emissions while maintaining or increasing milk production
(The University of Waikato, 2018)Rising global population is driving the requirement for more sustainable food production. Although, pastoral milk production efficiency has improved to meet demand, the intensification of practices has simultaneously ... -
Identification of central circuitry components mediating anorexigenic properties of oxytocin
(The University of Waikato, 2019)Recent years have brought exciting discoveries showing that a neurohormone, oxytocin (OT), acts as an appetite suppressant. Importantly, OT decreases energy needs-driven consumption of high-calorie foods by promoting early ... -
Identification of central mechanisms underlying statin-induced changes in consummatory behaviour in rats
(University of Waikato, 2017)Simvastatin is a cholesterol lowering statin whose adverse effects include an increase in appetite and, consequently, obesity. This is counterproductive to the otherwise beneficial outcomes of simvastatin on metabolic and ... -
Improving bovine donor cell culture conditions for embryo-derived cell transfer cloning
(The University of Waikato, 2021)Cloning by cell transfer offers an efficient method for increasing genetic gain in livestock populations. High-quality genes are routinely induced into embryos with artificial selection-based in vitro fertilisation, or ... -
Insensitivity to anorexigenic effects of naltrexone in the VPA rat model of autism
(The University of Waikato, 2022)Autism spectrum disorder (ASD) is a complex disorder whose etiology lies in, among others, abnormal neural processing, and improper neural circuitry development. This results in a plethora of aberrant behaviors, including ... -
Neuromolecular basis of anomalous feeding behaviour in the valproate rat model of autism
(The University of Waikato, 2023)Autism spectrum disorder (ASD), which affects circa 1% of the global population, is characterized by impairments in social communication, interaction, language disability, sensory anomalies, repetitive behaviours, and ... -
Oxytocin and Vasopressin Neuronal Activity In Response to Novel Versus Familiar Object Exposure In Mice
(University of Waikato, 2016)Oxytocin (OT) and vasopressin (AVP), peptides synthesised in the hypothalamic supraoptic and paraventricular nuclei, are released during the introduction to a familiar or novel stimulus in low-stress social and environmental ...
