Browsing by Subject "EXPRESSION"

Now showing items 1-3 of 3

  • Crystal structure of pyruvate decarboxylase from Zymobacter palmae

    Buddrus, Lisa; Andrews, Emma Sophie Vout; Leak, David J.; Danson, Michael J.; Arcus, Vickery L.; Crennell, Susan J. (International Union of Crystallography, 2016)
    Pyruvate decarboxylase (PDC; EC 4.1.1.1) is a thiamine pyrophosphate- and Mg²⁺ ion-dependent enzyme that catalyses the non-oxidative decarboxylation of pyruvate to acetaldehyde and carbon dioxide. It is rare in bacteria, ...
  • Post-transcriptional modulation of the SigF regulon inMycobacterium smegmatisby the PhoH2 toxin-antitoxin

    Andrews, Emma Sophie Vout; Rzoska-Smith, Elizabeth; Arcus, Vickery L. (Public Library Science, 2020)
    PhoH2 proteins are highly conserved across bacteria and archaea yet their biological function is poorly characterised. We examined the growth profiles of Mycobacterium smegmatis strains mc²155 and mc²155 ΔphoH2 and observed ...
  • Transcriptional changes in response to ketamine ester-analogs SN 35210 and SN 35563 in the rat brain

    Jacobson, Gregory M.; Voss, Logan J.; Klockars, Anica; Bird, Steve; Dimitrov, Ivo; Denny, William A.; Olszewski, Pawel K.; Sleigh, James W.; Harvey, Martyn G. (BMC, 2019)
    Background Ketamine ester analogs, SN 35210 and SN 35563, demonstrate different pharmacological profiles to ketamine in animal models. Both confer hypnosis with predictably rapid offset yet, paradoxically, SN35563 induces ...