Show simple item record  

dc.contributor.advisorPeters, Linda M.
dc.contributor.authorSagvekar, Pranjali
dc.date.accessioned2018-07-17T03:30:18Z
dc.date.available2018-07-17T03:30:18Z
dc.date.issued2018
dc.identifier.citationSagvekar, P. (2018). Functional Analysis of Vitelline Membrane Outer Layer 1 (VMO1) (Thesis, Master of Science (MSc)). The University of Waikato, Hamilton, New Zealand. Retrieved from https://hdl.handle.net/10289/11960en
dc.identifier.urihttps://hdl.handle.net/10289/11960
dc.description.abstractHearing loss is an auditory impairment affecting millions of people world-wide. It has considerable impact psychologically, socially, and physically in adults; with the affected numbers increasing with age, and those with learning disabilities are at a particular risk. With the current advancements in audiological technologies and research related to regeneration of inner ear cells, it is important to understand hearing loss at a molecular level and the proteins involved in the mechanism. Because of the many complications involved in isolating genes from the actual human ear, the use of animal/bacterial models and commercial mammalian cell lines have become important and informative. In addition, bioinformatics analysis makes it possible to converge the similarities between the human genome and genes from other species in real time. This aids in screening the genetic causes which underlie hearing loss and improve our understanding to unravel diagnostic strategies. The Vitelline Membrane Outer Layer 1 homolog (Vmo1) gene is of particular interest as it was uniquely and highly expressed in the inner ear of mouse. The function of this gene is currently unknown. The aim of this research is to induce recombinant human VMO1 protein in a prokaryotic system (E. coli) and ascertain its expression using a range of molecular and cellular assays. To do so, this research focuses on four objectives.
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherThe University of Waikato
dc.rightsAll items in Research Commons are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.titleFunctional Analysis of Vitelline Membrane Outer Layer 1 (VMO1)
dc.typeThesis
thesis.degree.grantorThe University of Waikato
thesis.degree.levelMasters
thesis.degree.nameMaster of Science (MSc)
dc.date.updated2018-07-01T19:10:36Z
pubs.place-of-publicationHamilton, New Zealanden_NZ


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record