Research Commons
      • Browse 
        • Communities & Collections
        • Titles
        • Authors
        • By Issue Date
        • Subjects
        • Types
        • Series
      • Help 
        • About
        • Collection Policy
        • OA Mandate Guidelines
        • Guidelines FAQ
        • Contact Us
      • My Account 
        • Sign In
        • Register
      View Item 
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Biophysical modeling of neural plasticity induced by transcranial magnetic stimulation

      Wilson, Marcus T.; Fulcher, Ben D.; Fung, Park K.; Robinson, P.A.; Fornito, Alex; Rogasch, Nigel C.
      Thumbnail
      Files
      TMS_modelling_paper_as_submitted_Feb_2018.pdf
      Submitted version, 1.035Mb
      DOI
       10.1016/j.clinph.2018.03.018
      Find in your library  
      Citation
      Export citation
      Wilson, M. T., Fulcher, B. D., Fung, P. K., Robinson, P. A., Fornito, A., & Rogasch, N. C. (2018). Biophysical modeling of neural plasticity induced by transcranial magnetic stimulation. Clinical Neurophysiology, 129(6), 1230–1241. https://doi.org/10.1016/j.clinph.2018.03.018
      Permanent Research Commons link: https://hdl.handle.net/10289/11994
      Abstract
      Transcranial magnetic stimulation (TMS) is a widely used noninvasive brain stimulation method capable of inducing plastic reorganisation of cortical circuits in humans. Changes in neural activity following TMS are often attributed to synaptic plasticity via process of long-term potentiation and depression (LTP/LTD). However, the precise way in which synaptic processes such as LTP/LTD modulate the activity of large populations of neurons, as stimulated en masse by TMS, are unclear. The recent development of biophysical models, which incorporate the physiological properties of TMS-induced plasticity mathematically, provide an excellent framework for reconciling synaptic and macroscopic plasticity. This article overviews the TMS paradigms used to induce plasticity, and their limitations. It then describes the development of biophysically-based numerical models of the mechanisms underlying LTP/LTD on population-level neuronal activity, and the application of these models to TMS plasticity paradigms, including theta burst and paired associative stimulation. Finally, it outlines how modeling can complement experimental work to improve mechanistic understandings and optimize outcomes of TMS-induced plasticity.
      Date
      2018
      Type
      Journal Article
      Publisher
      Elsevier
      Rights
      This is an author’s submitted version of an article published in the journal: Clinical Neurophysiology. © 2018 Elsevier.
      Collections
      • Science and Engineering Papers [3142]
      Show full item record  

      Usage

      Downloads, last 12 months
      70
       
       
       

      Usage Statistics

      For this itemFor all of Research Commons

      The University of Waikato - Te Whare Wānanga o WaikatoFeedback and RequestsCopyright and Legal Statement