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dc.contributor.authorWilson, Marcus T.en_NZ
dc.contributor.editorHillman, K.en_NZ
dc.coverage.spatialQueenstown, New Zealanden_NZ
dc.date.accessioned2019-02-19T02:02:49Z
dc.date.available2018-08-29en_NZ
dc.date.available2019-02-19T02:02:49Z
dc.date.issued2018en_NZ
dc.identifier.citationWilson, M. T. (2018). Using neural fields to model motor evoked potentials due to transcranial magnetic stimulation. In K. Hillman (Ed.), Proceedings of the 36th International Australasian Winter Conference on Brain Research. Queenstown, New Zealand.en
dc.identifier.issn1176-3183en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/12348
dc.description.abstractNeural field models, in which populations of neurons are described through ensemble-averaged properties such as firing rate and axonal flux, have been well-used to describe electroencephalogram (EEG) effects in natural sleep, anaesthesia and epilepsy. Changes in EEG due to stimulation by electromagnetic fields have also been studied. However, experimental data concerning transcranial magnetic stimulation (TMS) is dominated by measurements of motor-evoked potentials (MEPs). To use neural fields for TMS, a model of the MEP is required. In this work, an existing model has been augmented by addition of populations of cells describing stages of the MEP pathway previously neglected by neural field models. The model includes coupled populations of excitatory and inhibitory layer 2/3 cortical neurons, stimulated by an external field. These populations feed an additional population of layer 5 neurons, which also couples weakly to the external field. The layer 5 neurons feed motoneurons, from which a measure of the motor-evoked potential is constructed. After some tuning of parameters, the extra populations have resulted in a better model of the MEP than previously present in neural field models. The model reproduces the non-linear response to an increase in stimulation amplitude. With a paired-pulse protocol it reproduces the experimental effects of intracortical facilitation and long-interval intracortical inhibition, though it shows only weak short-interval intracortical inhibition. The experimental direct and indirect waves of activation from the layer 5 neurons are not adequately reproduced. Small changes in synaptic weight can give much greater changes in MEP response. In conclusion, the model is promising but it raises questions about whether neural field models are really appropriate for the study of many TMS effects.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.sourceAustralasian Winter Conference on Brain Research 2018en_NZ
dc.titleUsing neural fields to model motor evoked potentials due to transcranial magnetic stimulationen_NZ
dc.typeConference Contribution
dc.relation.isPartOfProceedings of the 36th International Australasian Winter Conference on Brain Researchen_NZ
pubs.elements-id226682
pubs.finish-date2018-08-29en_NZ
pubs.publisher-urlhttps://www.otago.ac.nz/awcbr/proceedings/otago694586.pdfen_NZ
pubs.start-date2018-08-25en_NZ


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