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dc.contributor.authorKavtaradze, Levan K.en_US
dc.contributor.authorManley-Harris, Merilynen_US
dc.contributor.authorNicholson, Brian K.en_US
dc.coverage.spatialUnited Statesen_NZ
dc.date.accessioned2008-03-19T05:10:11Z
dc.date.available2007-08-30en_US
dc.date.available2008-03-19T05:10:11Z
dc.date.issued2004-09-01en_US
dc.identifier.citationKavtaradze, L.K., Manley-Harris, M. & Nicholson, B.K. (2004). A low toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures. Steroids, 69, 697-700.en_US
dc.identifier.urihttps://hdl.handle.net/10289/158
dc.description.abstractWe describe an inexpensive, low-toxicity and high-yielding method for the production of pure lanosterol and dihydrolanosterol from the commercially available mixture. Optimum conditions are presented for the one-pot production of the intermediate 24,25 vicinal diol of lanosterol acetate (via either epoxidation or hydroxyhalogenation) which is readily separated from the unreacted dihydrolanosterol acetate. The lanosterol diol can then be converted to pure (>97%) lanosterol. Hypophosphorous acid was used for both the conversion of the epoxide to the diol, and as a catalyst for the hydroxyhalogenation by N-halosuccinimides of the olefinic bond.en_US
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherElsevier Inc.en_NZ
dc.relation.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/504090/description#descriptionen_US
dc.rightsThis is an authors version of an article published in the journal, Steroids, (c) 2004 Elsevier Inc.en_US
dc.subjectlanosterolen_US
dc.subjectdihydrolanosterolen_US
dc.subjecthydroxyhalogenationen_US
dc.subjectdihydroxylationen_US
dc.subjecthypophosphorous aciden_US
dc.titleA low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixturesen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/j.steroids.2004.07.003en_US
dc.relation.isPartOfSteroidsen_NZ
pubs.begin-page697en_NZ
pubs.elements-id30276
pubs.end-page700en_NZ
pubs.issue10en_NZ
pubs.volume69en_NZ


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