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dc.contributor.authorChalmers, Rebecca A.en_NZ
dc.contributor.authorCervin, Mattien_NZ
dc.contributor.authorChoo, Carolen_NZ
dc.contributor.authorBaune, BTen_NZ
dc.contributor.authorTrollor, JNen_NZ
dc.contributor.authorNumbers, Ken_NZ
dc.contributor.authorSachdev, PSen_NZ
dc.contributor.authorBrodaty, Hen_NZ
dc.contributor.authorKochan, NAen_NZ
dc.contributor.authorMedvedev, Oleg N.en_NZ
dc.coverage.spatialGermanyen_NZ
dc.date.accessioned2023-10-15T22:53:51Z
dc.date.available2023-10-15T22:53:51Z
dc.date.issued2022-10en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/16080
dc.description.abstractBACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoengen_NZ
dc.publisherSpringer
dc.rights© 2022 The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
dc.subjectAgingen_NZ
dc.subjectBiomarkersen_NZ
dc.subjectCognitionen_NZ
dc.subjectDepressionen_NZ
dc.subjectNetwork analysisen_NZ
dc.subjectAgeden_NZ
dc.subjectFemaleen_NZ
dc.subjectHumansen_NZ
dc.subjectMaleen_NZ
dc.subjectBiomarkersen_NZ
dc.subjectCognitionen_NZ
dc.subjectDepressionen_NZ
dc.subjectInflammationen_NZ
dc.subjectMemoryen_NZ
dc.subjectAged, 80 and overen_NZ
dc.titleNetworks of inflammation, depression, and cognition in aging males and females.en_NZ
dc.typeJournal Article
dc.identifier.doi10.1007/s40520-022-02198-6en_NZ
dc.relation.isPartOfAging Clin Exp Resen_NZ
pubs.begin-page2387
pubs.elements-id272351
pubs.end-page2398
pubs.issue10en_NZ
pubs.publication-statusPublisheden_NZ
pubs.volume34en_NZ
dc.identifier.eissn1720-8319en_NZ


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