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dc.contributor.authorNicholson, Brian K.en_US
dc.contributor.authorHenderson, Williamen_US
dc.contributor.authorDinger, Maarten B.en_US
dc.date.accessioned2008-03-19T05:08:20Z
dc.date.available2007-11-14en_US
dc.date.available2008-03-19T05:08:20Z
dc.date.issued2003-11-01en_US
dc.identifier.citationNicholson, B. K., Henderson, W. & Dinger, M.B. (2003). Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand. Inorganica Chimica Acta, 355, 428-431.en_US
dc.identifier.urihttps://hdl.handle.net/10289/198
dc.description.abstractReaction of N,N′-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)2] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)2] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(=NPh)NPh}(PPh3)2], with a Pt---Se---C---N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II)-thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)2] showed high activity [IC50 1.0 μM], with the other complexes showing moderate to low activity.en_US
dc.language.isoen
dc.publisherElsevieren_NZ
dc.relation.urihttp://www.sciencedirect.com.ezproxy.waikato.ac.nz:2048/science?_ob=ArticleURL&_udi=B6TG5-4967H5K-3&_user=100025&_coverDate=11%2F20%2F2003&_rdoc=57&_fmt=full&_orig=browse&_srch=doc-info(%23toc%235245%232003%23996449999%23472326%23FLA%23display%23Volume)&_cdi=5245&_sort=d&_docanchor=&view=g&_ct=65&_acct=C000007699&_version=1&_urlVersion=0&_userid=100025&md5=66798de8b4f796855e3ce52dd1e07e49en_US
dc.rightsThis article is published in the journal Inorganica Chimica Acta, (c) 2003 Elsevier B.V.en_US
dc.subjectPlatinum complexesen_US
dc.subjectSelenourea dianionen_US
dc.subjectThiourea dianionen_US
dc.subjectCrystal structuresen_US
dc.subjectAnticancer activityen_US
dc.titleSynthesis and crystal structure of the first complex containing a chelating selenourea dianion liganden_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1016/S0020-1693(03)00298-6en_US
dc.relation.isPartOfInorganica Chimica Actaen_NZ
pubs.begin-page428en_NZ
pubs.elements-id29611
pubs.end-page431en_NZ
pubs.volume355en_NZ
uow.identifier.article-noCen_NZ


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