The composition of Ehrlich's salvarsan: Resolution of a century-old debate

Lloyd, Nicholas C.; Morgan, Hugh W.; Nicholson, Brian K.; Ronimus, Ron S.

doi:10.1002/anie.200461471

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Lloyd, N.C., Morgan, H.W., Nicholson, B.K. & Ronimus, R.S. (2005). The composition of Ehrlichs Salvarsan; resolution of a century-old debate, Angew. Chem. Int. Ed., 44, 941-944.

Permanent Research Commons link: https://hdl.handle.net/10289/207

Abstract

Ehrlich introduced in 1910 the compound 3-amino-4-hydroxyphenylarsenic(I) [Salvarsan, arsphenamine, Ehrlich 606,] as a remedy for syphilis, a disease caused by the spirochaete bacterium Treponema pallidum. His methodical search for a specific curative for an identified disease can be regarded as the introduction of targeted chemotherapy.

Date

2004-08-01

Type

Journal Article

Publisher

Wiley-VCH Verlag GmbH & Co. KGaA

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Science and Engineering Papers [3124]