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dc.contributor.authorTripathi, Ashootosh
dc.contributor.authorPuddick, Jonathan
dc.contributor.authorPrinsep, Michèle R.
dc.contributor.authorLee, Peter Peng Foo
dc.contributor.authorTan, Lik Tong
dc.coverage.spatialUnited Statesen_NZ
dc.date.accessioned2009-07-08T02:48:18Z
dc.date.available2009-07-08T02:48:18Z
dc.date.issued2009
dc.identifier.citationTripathi, A., Puddick, J., Prinsep, M.R., Lee, P.P.F. & Tan, L.T. (2009). Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula. Journal of Natural Products, 72(1), 29-32.en
dc.identifier.issn1520-6025
dc.identifier.urihttps://hdl.handle.net/10289/2219
dc.description.abstractChemical investigation of the marine cyanobacterium Lyngbya majuscula from Pulau Hantu Besar, Singapore, has led to the isolation of a cyclodepsipeptide, hantupeptin A (1). The planar structure of 1 was assigned on the basis of extensive 1D and 2D NMR spectroscopic experiments. The absolute configuration of the amino and hydroxyl acid residues in the molecule was determined by application of the advanced Marfey method, chiral HPLC analysis, and Mosher’s method. Hantupeptin A showed cytotoxicity to MOLT-4 leukemia cells and MCF-7 breast cancer cells with IC50 values of 32 and 4.0 µM, respectively.en
dc.language.isoen
dc.publisherAmerican Chemical Societyen_NZ
dc.subjectchemistryen
dc.titleHantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majusculaen
dc.typeJournal Articleen
dc.identifier.doi10.1021/np800448ten
dc.relation.isPartOfJournal of Natural Productsen_NZ
pubs.begin-page29en_NZ
pubs.elements-id34088
pubs.end-page32en_NZ
pubs.issue1en_NZ
pubs.volume72en_NZ


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