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dc.contributor.authorPrinsep, Michèle R.en_US
dc.contributor.authorYao, Biaoen_US
dc.contributor.authorNicholson, Brian K.en_US
dc.contributor.authorGordon, Dennis P.en_US
dc.date.accessioned2008-03-19T05:10:52Z
dc.date.available2007-10-22en_US
dc.date.available2008-03-19T05:10:52Z
dc.date.issued2004-01-01en_US
dc.identifier.citationPrinsep, M.R., Yao, B., Nicholson, B.K. & Gordon, D.P. (2004). The pterocellins, bioactive alkaloids from the marine Bryozoan Pterocella vesiculosa. Phytochemistry Reviews, 3(3), 325-331.en_US
dc.identifier.urihttps://hdl.handle.net/10289/222
dc.description.abstractAlthough comparatively little research has been undertaken into the secondary metabolites of bryozoans as compared with those of other marine invertebrates, bryozoans have proven to be an excellent source of novel and/or biologically active compounds. The majority of bryozoan metabolites isolated to date have been alkaloids. In our continuing search for bioactive and/or novel compounds from New Zealand marine bryozoans, we undertook an investigation of an extract of Pterocella vesiculosa (order Cheilostomatida, suborder Ascophorina, family Catenicellidae) which possessed activity against P388 murine leukaemia cells. Two alkaloids, pterocellins A-B (1-2) have been isolated from the bryozoan. The biological activity of these alkaloids was examined including their activities in the in vitro 60 cell line panel and in vivo hollow fibre assays at the National Cancer Institute (NCI). The isolation and characterisation of further pterocellin analogues is currently in progress and tentative structures for two new members of this series, pterocellins C-D (3-4) are proposed, based on NMR and mass spectral data.en_US
dc.language.isoen
dc.publisherSpringer Verlag Dordrechten_NZ
dc.relation.urihttp://www.springerlink.com.ezproxy.waikato.ac.nz:2048/content/h691663235260313/?p=e93ed356b6d14528a7e6e49bc360f6c4&pi=5en_US
dc.rightsThis article is published in the journal Phytochemistry Reviews , (c) Springer.en_US
dc.subjectAlkaloiden_US
dc.subjectbryozoanen_US
dc.subjectPterocella vesiculosaen_US
dc.titleThe pterocellins, bioactive alkaloids from the marine bryozoan Pterocella vesiculosaen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1007/s11101-004-6146-2en_US
dc.relation.isPartOfPhytochemistry Reviewsen_NZ
pubs.begin-page325en_NZ
pubs.editionJanuaryen_NZ
pubs.elements-id30753
pubs.end-page331en_NZ
pubs.issue3en_NZ
pubs.volume3en_NZ


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