Synthesis, characterisation and biological activity of gold(III) catecholate and related complexes
Citation
Export citationGoss, C. H. A., Henderson, W., Wilkins, A. L., & Evans, C. (2003). Synthesis, characterisation and biological activity of gold(III) catecholate and related complexes. Journal of Organometallic Chemistry, 679(2), 194-201.
Permanent Research Commons link: https://hdl.handle.net/10289/3408
Abstract
The reactions of the cyclometallated gold(III) complexes [LAuCl₂] [L=2-(dimethylaminomethyl)phenyl, 2-benzylpyridyl or 2-anilinopyridyl] with catechol, tetrachlorocatechol, or the cyclic α,β-diketone SCH(CO2Et)C(O)C(O)CH(CO2Et) give stable complexes containing five-membered Au-O-C-C-O rings. These represent the first examples of well-characterised gold(III) catecholate complexes. Similarly, reactions with 2-acetamidophenol [HOC₆H₄NHC(O)CH₃] give complexes with the related Au---N---C---C---O ring. The complexes were characterised by NMR spectroscopy, electrospray ionisation mass spectrometry, elemental microanalysis, and in the case of the complex [(2-benzylpyridyl)Au{OC₆H₄NC(O)CH₃}] by an X-ray crystal structure determination. Several complexes show high activity towards P388 murine leukemia cells.
Date
2003Type
Publisher
Elsevier S.A.
Rights
This is an author’s accepted version of an article published in the Journal of Organometallic Chemistry. Copyright © 2003 Elsevier B.V. All rights reserved.