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dc.contributor.authorDaniel, Roy M.
dc.contributor.authorDunn, Rachel V.
dc.contributor.authorFinney, John L.
dc.contributor.authorSmith, Jeremy C.
dc.date.accessioned2010-08-29T21:45:47Z
dc.date.available2010-08-29T21:45:47Z
dc.date.issued2003
dc.identifier.citationDaniel, R.M., Dunn, R.V., Finney, J.L. & Smith, J.C. (2003). The role of dynamics in enzyme activity. Annual Review of Biophysics and Biomolecular Structure, 32, 69-92.en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/4452
dc.description.abstractAlthough protein function is thought to depend on flexibility, precisely how the dynamics of the molecule and its environment contribute to catalytic mechanisms is unclear. We review experimental and computational work relating to enzyme dynamics and function, including the role of solvent. The evidence suggests that fast motions on the 100 ps timescale, and any motions coupled to these, are not required for enzyme function. Proteins where the function is electron transfer, proton tunneling, or ligand binding may have different dynamical dependencies from those for enzymes, and enzymes with large turnover numbers may have different dynamical dependencies from those that turn over more slowly. The timescale differences between the fastest anharmonic fluctuations and the barrier-crossing rate point to the need to develop methods to resolve the range of motions present in enzymes on different time- and lengthscales.en_NZ
dc.language.isoen
dc.publisherAnnual Reviewsen_NZ
dc.relation.urihttps://www.annualreviews.org/doi/abs/10.1146/annurev.biophys.32.110601.142445en_NZ
dc.subjectprotein flexibilityen_NZ
dc.subjectenzyme stabilityen_NZ
dc.subjectdynamical transitionen_NZ
dc.subjectsolvationen_NZ
dc.subjecthydrationen_NZ
dc.titleThe role of dynamics in enzyme activityen_NZ
dc.typeJournal Articleen_NZ
dc.identifier.doi10.1146/annurev.biophys.32.110601.142445en_NZ
dc.relation.isPartOfAnnual Review of Biophysics and Biomolecular Structureen_NZ
pubs.begin-page69en_NZ
pubs.editionJuneen_NZ
pubs.elements-id28349
pubs.end-page92en_NZ
pubs.issue1en_NZ
pubs.volume32en_NZ


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