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dc.contributor.authorTripathi, Ashootosh
dc.contributor.authorPuddick, Jonathan
dc.contributor.authorPrinsep, Michèle R.
dc.contributor.authorRottmann, Matthias
dc.contributor.authorTan, Lik Tong
dc.coverage.spatialUnited Statesen_NZ
dc.date.accessioned2011-02-16T22:44:56Z
dc.date.available2011-02-16T22:44:56Z
dc.date.issued2010
dc.identifier.citationTripathi, A., Puddick, J., Prinsep, M.R., Rottmann, M. & Tan, L.T. (2010). Lagunamides A and B: Cytotoxic and antimalarial Cyclodepsipeptides from the Marine cyanobacterium Lyngbya majuscule. Journal of Natural Products, 73(11), 1810-1814.en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/5058
dc.description.abstractLagunamides A (1) and B (2) are new cyclic depsipeptides isolated from the marine cyanobacterium Lyngbya majuscula obtained from Pulau Hantu Besar, Singapore. The planar structural characterization of these molecules was achieved by extensive spectroscopic analysis, including 2D NMR experiments. In addition to Marfey’s method and 3JH−H coupling constant values, a modified method based on Mosher’s reagents and analysis using LC-MS was deployed for the determination of the absolute configuration. Lagunamides A and B displayed significant antimalarial properties, with IC₅₀ values of 0.19 and 0.91 μM, respectively, when tested against Plasmodium falciparum. Lagunamides A and B also possessed potent cytotoxic activity against P388 murine leukemia cell lines, with IC₅₀ values of 6.4 and 20.5 nM, respectively. Furthermore, these cyanobacterial compounds exhibited moderate antiswarming activities when tested against Pseudomonas aeruginosa PA01.en_NZ
dc.language.isoen
dc.publisherACS Publicationsen_NZ
dc.relation.urihttp://pubs.acs.org/doi/abs/10.1021/np100442xen_NZ
dc.subjectchemistryen_NZ
dc.titleLagunamides A and B: Cytotoxic and antimalarial Cyclodepsipeptides from the Marine cyanobacterium Lyngbya majusculeen_NZ
dc.typeJournal Articleen_NZ
dc.identifier.doi10.1021/np100442xen_NZ
dc.relation.isPartOfJournal of Natural Productsen_NZ
pubs.begin-page1810en_NZ
pubs.elements-id35725
pubs.end-page1814en_NZ
pubs.issue11en_NZ
pubs.volume73en_NZ


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