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dc.contributor.authorJacobson, Gregory M.
dc.contributor.authorVoss, Logan J.
dc.contributor.authorMelin, Sofia M.
dc.contributor.authorCursons, Raymond T.
dc.contributor.authorSleigh, James W.
dc.date.accessioned2011-03-29T00:50:29Z
dc.date.available2011-03-29T00:50:29Z
dc.date.issued2011
dc.identifier.citationJacobson, G.M., Voss, L.J., Melin, S.M., Cursons, R.T. & Sleigh, J.W. (2011). The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice. Anaesthesia, available online 18 March 2011.en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/5209
dc.description.abstractGap junction blockade is a possible mechanism by which general anaesthetic drugs cause unconsciousness. We measured the sensitivity of connexin36 knockout mice to the hypnotic effects of isoflurane and propofol. The experimental endpoint was recovery of the righting reflex of the anaesthetised animals during 0.2% step-reductions in isoflurane concentration, or following intraperitoneal injection of propofol (100 mg.kg⁻¹). Connexin36 knockout animals were more sensitive to the hypnotic effects of isoflurane than ‘normal’ wild-type animals. The half maximal effective concentration (EC50) for recovery of righting reflex was 0.37% for connexin36 knockout vs 0.49% for wild-type animals (p < 0.001). For propofol, connnexin36 knockout animals showed more rapid loss of righting reflex than wild-type animals (mean (SD) 2.8 (0.13) vs 3.8 (0.27) min); and young (< 60 days) connexin36 knockout animals remained anaesthetised for longer than young wild-type mice (47.2 (2.9) vs 30.5 (1.7) min; p < 0.00001). These findings suggest that the hypnotic effects of anaesthetic drugs may be moderately enhanced by gap junction blockade.en_NZ
dc.language.isoen
dc.relation.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.2011.06658.x/abstracten_NZ
dc.rightsThis is an author’s accepted version of an article published in the journal: Asian Christian Review. Used with permission.en_NZ
dc.subjectConnexin36en_NZ
dc.titleThe role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in miceen_NZ
dc.typeJournal Articleen_NZ
dc.identifier.doi10.1111/j.1365-2044.2011.06658.xen_NZ


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