dc.contributor.author | Martinus, Ryan Dennis | |
dc.contributor.author | Cook, Christian | |
dc.coverage.spatial | England | en_NZ |
dc.date.accessioned | 2011-07-19T23:07:15Z | |
dc.date.available | 2011-07-19T23:07:15Z | |
dc.date.issued | 2011-08 | |
dc.identifier.citation | Martinus, R. & Cook, C. (2011). The effect of complement C5a on mitochondrial functions of PC12 cells. Neuroreport, 22(2), 581-585. | en_NZ |
dc.identifier.uri | https://hdl.handle.net/10289/5494 | |
dc.description.abstract | C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during apoptosis, we investigated mitochondria as a potential target for C5a. Using PC12 cells, we demonstrated that exposure to C5a led to inhibition of mitochondrial respiration, dehydrogenase and cytochrome c oxidase activities. Interestingly, an increase in expression of the mitochondrial stress protein chaperonin 60 was also observed, confirming a marked effect of C5a on mitochondrial functions. These observations are the first documented intracellular effects noted for the complement molecule C5a in in-vitro cultured cells. | en_NZ |
dc.language.iso | en | |
dc.publisher | Lippincott Williams & Wilkins | en_NZ |
dc.relation.uri | http://journals.lww.com/neuroreport/Abstract/2011/08240/The_effect_of_complement_C5a_on_mitochondrial.4.aspx | en_NZ |
dc.subject | C5a | en_NZ |
dc.subject | central nervous system | en_NZ |
dc.title | The effect of complement C5a on mitochondrial functions of PC12 cells | en_NZ |
dc.type | Journal Article | en_NZ |
dc.identifier.doi | 10.1097/WNR.0b013e32834901d9 | en_NZ |
dc.relation.isPartOf | NeuroReport | en_NZ |
pubs.begin-page | 581 | en_NZ |
pubs.elements-id | 36092 | |
pubs.end-page | 585 | en_NZ |
pubs.issue | 12 | en_NZ |
pubs.volume | 22 | en_NZ |