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dc.contributor.authorSleigh, James W.
dc.contributor.authorSteyn-Ross, Moira L.
dc.contributor.authorSteyn-Ross, D. Alistair
dc.contributor.authorVoss, Logan J.
dc.contributor.authorWilson, Marcus T.
dc.date.accessioned2013-04-22T21:35:48Z
dc.date.available2013-04-22T21:35:48Z
dc.date.copyright2010-10-24
dc.date.issued2010
dc.identifier.citationSleigh, J., Steyn-Ross, M., Steyn-Ross, A., Voss, L., & Wilson, M. (2010). Anesthesia-induced state transitions in neuronal populations. In A. Hudetz & R. Pearce (Eds.), Suppressing the mind: Contemporary clinical neuroscience (pp. 139-160). New York, NY: Humana Press.en_NZ
dc.identifier.issn9781-607614630
dc.identifier.urihttps://hdl.handle.net/10289/7509
dc.description.abstractIt is a simple observation that the function of the central nervous system changes abruptly at certain critical brain concentrations of the anesthetic drug. This can be viewed as analogous to “state transitions” in systems of interacting particles, which have been extensively studied in the physical sciences. Theoretical models of the electroencephalogram (EEG) are in semi-quantitative agreement with experimental data and show some features suggestive of anesthetic-induced state transitions (critical slowing, the biphasic effect, increase in spatial correlations, and entropy changes). However, the EEG is only an indirect marker of the (unknown) networks of cortical connectivity that are required for the formation of consciousness. It is plausible that anesthetic-induced alteration in cortical and corticothalamic network topology prevents the formation of a giant component in the neuronal population network, and hence induces unconsciousness.en_NZ
dc.language.isoen
dc.publisherHumana Press.en_NZ
dc.subjectGeneral anesthesiaen_NZ
dc.subjectstate transitionsen_NZ
dc.subjectconsciousnessen_NZ
dc.subjectentropyen_NZ
dc.subjectnetworksen_NZ
dc.subjectcontinuum modelsen_NZ
dc.titleAnesthesia-induced state transitions in neuronal populationsen_NZ
dc.typeChapter in Booken_NZ
dc.identifier.doi10.1007/978-1-60761-462-3_7en_NZ
dc.relation.isPartOfSuppressing the Mind: Anesthetic Modulation of Memory and Consciousnessen_NZ
pubs.begin-page139en_NZ
pubs.elements-id9739
pubs.end-page160en_NZ
pubs.place-of-publicationNew Yorken_NZ


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