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dc.contributor.authorChen, Jun
dc.contributor.authorXu, Qiaoqing
dc.contributor.authorWang, Tiehui
dc.contributor.authorCollet, Bertrand
dc.contributor.authorCorripio-Miyar, Yolanda
dc.contributor.authorBird, Steve
dc.contributor.authorXie, Ping
dc.contributor.authorNie, Pin
dc.contributor.authorSecombes, Christopher J.
dc.contributor.authorZou, Jun
dc.coverage.spatialUnited Statesen_NZ
dc.identifier.citationChen, J., Xu, Q., Wang, T., Collet, B., Corripio-Miyar, Y., ..., Zou, J. (2013). Phylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fish. Developmental & Comparative Immunology, 41(2), 137-152.en_NZ
dc.description.abstractIn this study, we have identified 421 molecules across the vertebrate spectrum and propose a unified nomenclature for CXC chemokines in fish, amphibians and reptiles based on phylogenetic analysis. Expanding on earlier studies in teleost fish, lineage specific CXC chemokines that have no apparent homologues in mammals were confirmed. Furthermore, in addition to the two subgroups of the CXCL8 homologues known in teleost fish, a third group was identified (termed CXCL8_L3), as was a further subgroup of the fish CXC genes related to CXCL11. Expression of the CXC chemokines found in rainbow trout, Oncorhynchus mykiss, was studied in response to stimulation with inflammatory and antiviral cytokines, and bacterial. Tissue distribution analysis revealed distinct expression profiles for these trout CXC chemokines. Lastly three of the trout chemokines, including two novel fish specific CXC chemokines containing three pairs of cysteines, were produced as recombinant proteins and their effect on trout leucocyte migration studied. These molecules increased the relative expression of CD4 and MCSFR in migrated cells in an in vitro chemotaxis assay.en_NZ
dc.relation.ispartofDevelopmental & Comparative Immunology
dc.subjectCXC chemokinesen_NZ
dc.titlePhylogenetic analysis of vertebrate CXC chemokines reveals novel lineage specific groups in teleost fishen_NZ
dc.typeJournal Articleen_NZ
dc.relation.isPartOfDevelopmental & Comparative Immunologyen_NZ

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