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dc.contributor.authorMolan, Peter C.
dc.contributor.authorRhodes, Tanya
dc.date.accessioned2015-08-21T04:20:57Z
dc.date.available2015-08-21T04:20:57Z
dc.date.issued2015
dc.identifier.citationMolan, P. C., & Rhodes, T. (2015). Honey: A biologic wound dressing. Wounds, 27(6), 141–151.en
dc.identifier.urihttps://hdl.handle.net/10289/9553
dc.description.abstractHoney has been used as a wound dressing for thousands of years, but only in more recent times has a scientific explanation become available for its effectiveness. It is now realized that honey is a biologic wound dressing with multiple bioactivities that work in concert to expedite the healing process. The physical properties of honey also expedite the healing process: its acidity increases the release of oxygen from hemoglobin thereby making the wound environment less favorable for the activity of destructive proteases, and the high osmolarity of honey draws fluid out of the wound bed to create an outflow of lymph as occurs with negative pressure wound therapy. Honey has a broad-spectrum antibacterial activity, but there is much variation in potency between different honeys. There are 2 types of antibacterial activity. In most honeys the activity is due to hydrogen peroxide, but much of this is inactivated by the enzyme catalase that is present in blood, serum, and wound tissues. In manuka honey, the activity is due to methylglyoxal which is not inactivated. The manuka honey used in wound-care products can withstand dilution with substantial amounts of wound exudate and still maintain enough activity to inhibit the growth of bacteria. There is good evidence for honey also having bioactivities that stimulate the immune response (thus promoting the growth of tissues for wound repair), suppress inflammation, and bring about rapid autolytic debridement. There is clinical evidence for these actions, and research is providing scientific explanations for them.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoenen_NZ
dc.relation.urihttp://www.woundsresearch.com/article/honey-biologic-wound-dressingen_NZ
dc.rightsThis article has been published in the journal: Wounds. Used with permission.en_NZ
dc.subjectbiology of wound healingen_NZ
dc.subjectcomponents of wound healingen_NZ
dc.subjecthoneyen_NZ
dc.subjectwound dressingen_NZ
dc.titleHoney: A biologic wound dressingen_NZ
dc.typeJournal Articleen_NZ
dc.relation.isPartOfWounds
pubs.begin-page141
pubs.end-page151
pubs.issue6
pubs.volume27


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