Show simple item record  

dc.contributor.authorCursons, Raymond T.en_NZ
dc.contributor.authorPatty, Oliviaen_NZ
dc.contributor.authorZhang, Hengen_NZ
dc.contributor.authorSteward, Karenen_NZ
dc.contributor.authorWaller, Andrew S.en_NZ
dc.date.accessioned2016-02-22T00:55:33Z
dc.date.available2015en_NZ
dc.date.available2016-02-22T00:55:33Z
dc.date.issued2015en_NZ
dc.identifier.citationCursons, R. T., Patty, O., Zhang, H., Steward, K., & Waller, A. S. (2015). Diagnostic dilemmas associated with the pinnacle IN vaccine. Presented at the Havemeyer Foundation Workshop, Getting to Grips with Strangles and other Streptococcal Diseases, May 20-22, 2015, Elsinore, Denmark.en
dc.identifier.urihttps://hdl.handle.net/10289/9938
dc.description.abstractThe development of clinical signs of strangles in horses following immunization with a live attenuated vaccine can present a number of diagnostic challenges. Foremost from an epidemiological perspective it is important to ascertain if the infection was due solely to the modified live vaccine, reversion of the vaccine strain to wild-type, recombination between vaccine and wild-type strains or to recent infection with a wild-type strain. To answer these diagnostics challenges we utilized next generation sequencing to confirm that two cases of strangles in previously healthy yearling horses were caused by the vaccine strain. Both isolates recovered from the two cases of vaccine-related strangles contained 67 of the 68 mutations specific for the Pinnacle vaccine. Our data shed new light on the safety of this vaccine and suggest that factors beyond the maturity of the animal’s immune system can influence the development of post-vaccination adverse reactions in some horsesen_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.relation.urihttp://www.havemeyerfoundation.org/workshops-group5.htm
dc.sourceGetting to grips with strangles and other Streptococcal diseases ,Elsinore Denmarken_NZ
dc.subjectStrangles, infection, live vaccine next generation sequencingen_NZ
dc.titleDiagnostic dilemmas associated with the pinnacle IN vaccineen_NZ
pubs.begin-page29
pubs.elements-id136090
pubs.end-page29
pubs.finish-date2015-05-22en_NZ
pubs.start-date2015-05-20en_NZ


Files in this item

This item appears in the following Collection(s)

Show simple item record