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Did primitive microorganisms use nonhem iron proteins in place of NAD/P?

Abstract
Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are of universal occurrence in living organisms and play a central role in coupling oxidative with reductive reactions. However, the evidence that the origin and early evolution of life occurred at high temperatures (>95°C) is now strong, and at these temperatures some modern metabolites, including both the reduced and oxidized forms of these coenzymes, are unstable. We believe there is good evidence that indicates that in the most primitive organisms nonhem iron proteins carried out many or all of the functions of NAD/P(H). This has important implications for the way in which investigations of archaebacterial metabolism are conducted.
Type
Journal Article
Type of thesis
Series
Citation
Daniel, R. M. & Danson, M.J. (1995). Did primitive microorganisms use nonhem iron proteins in place of NAD/P? Journal of Molecular Evolution, 40(6), 559-563.
Date
1995
Publisher
Springer
Degree
Supervisors
Rights